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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Foundas A L, Eure K F, Seltzer B

Department of Psychiatry and Neurology, Tulane University Medical Center, New Orleans, LA, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1131-44. doi: 10.1016/s0278-5846(96)00101-7.

Although volumetric Magnetic Resonance Imaging (MRI) studies suggest regional cortical atrophy in Alzheimer's disease (AD), only one prior study documented atrophy of the parietal and insular cortex (Foundas et al, 1993). 2. To further investigate this potential early marker of AD, the authors computed volumetric measures of these regions on conventional axial MRI sections in 25 patients with mild to moderate "probable AD" and 25 age- and sex-matched controls. 3. Regions of interest (ROIs) from T1-axial images (5mm) were scanned into a PCX format (400 dots/inch) and volumes of CSF fluid were calculated using an Autocad program. 4. AD patients showed significant parietal (p < .01) and insular (p < .002) atrophy as compared to controls. 5. These findings suggest that atrophy of the parietal and insular cortex may occur early in AD patients, and that certain quantitative measures on conventional MRI accurately discriminate AD patients from controls.

尽管容积磁共振成像（MRI）研究表明阿尔茨海默病（AD）存在局部皮质萎缩，但之前仅有一项研究记录了顶叶和岛叶皮质萎缩（丰达斯等人，1993年）。2. 为了进一步研究AD这种潜在的早期标志物，作者在25例轻度至中度“可能AD”患者以及25例年龄和性别匹配的对照者的常规轴向MRI切片上计算了这些区域的容积测量值。3. 将T1轴向图像（5毫米）的感兴趣区域（ROI）扫描成PCX格式（400点/英寸），并使用AutoCAD程序计算脑脊液体积。4. 与对照组相比，AD患者表现出显著的顶叶萎缩（p <.01）和岛叶萎缩（p <.002）。5. 这些发现表明，顶叶和岛叶皮质萎缩可能在AD患者中早期出现，并且常规MRI上的某些定量测量可以准确区分AD患者和对照者。

Foundas A L, Eure K F, Seltzer B

Department of Psychiatry and Neurology, Tulane University Medical Center, New Orleans, LA, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1996 Oct;20(7):1131-44. doi: 10.1016/s0278-5846(96)00101-7.

Although volumetric Magnetic Resonance Imaging (MRI) studies suggest regional cortical atrophy in Alzheimer's disease (AD), only one prior study documented atrophy of the parietal and insular cortex (Foundas et al, 1993). 2. To further investigate this potential early marker of AD, the authors computed volumetric measures of these regions on conventional axial MRI sections in 25 patients with mild to moderate "probable AD" and 25 age- and sex-matched controls. 3. Regions of interest (ROIs) from T1-axial images (5mm) were scanned into a PCX format (400 dots/inch) and volumes of CSF fluid were calculated using an Autocad program. 4. AD patients showed significant parietal (p < .01) and insular (p < .002) atrophy as compared to controls. 5. These findings suggest that atrophy of the parietal and insular cortex may occur early in AD patients, and that certain quantitative measures on conventional MRI accurately discriminate AD patients from controls.

尽管容积磁共振成像（MRI）研究表明阿尔茨海默病（AD）存在局部皮质萎缩，但之前仅有一项研究记录了顶叶和岛叶皮质萎缩（丰达斯等人，1993年）。2. 为了进一步研究AD这种潜在的早期标志物，作者在25例轻度至中度“可能AD”患者以及25例年龄和性别匹配的对照者的常规轴向MRI切片上计算了这些区域的容积测量值。3. 将T1轴向图像（5毫米）的感兴趣区域（ROI）扫描成PCX格式（400点/英寸），并使用AutoCAD程序计算脑脊液体积。4. 与对照组相比，AD患者表现出显著的顶叶萎缩（p <.01）和岛叶萎缩（p <.002）。5. 这些发现表明，顶叶和岛叶皮质萎缩可能在AD患者中早期出现，并且常规MRI上的某些定量测量可以准确区分AD患者和对照者。