Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermedia.
作者信息
Origa Raffaella, Cazzola Mario, Mereu Elisabetta, Danjou Fabrice, Barella Susanna, Giagu Nicolina, Galanello Renzo, Swinkels Dorine W
机构信息
Ospedale Microcitemico-Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy.
Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Italy.
出版信息
Haematologica. 2015 May;100(5):e169-71. doi: 10.3324/haematol.2014.115733. Epub 2015 Jan 16.
Abstract
摘要
相似文献
1
Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermedia.血红蛋白H病与中间型β地中海贫血之间红细胞生成-铁调素-铁储存轴的差异。
Haematologica. 2015 May;100(5):e169-71. doi: 10.3324/haematol.2014.115733. Epub 2015 Jan 16.
2
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.在血红蛋白Eβ地中海贫血和β地中海贫血特征中，促红细胞生成可抑制铁调素。
Blood. 2015 Jan 29;125(5):873-80. doi: 10.1182/blood-2014-10-606491. Epub 2014 Dec 17.
3
mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models.中间型β地中海贫血和重型β地中海贫血小鼠模型中铁调节基因的mRNA表达
Am J Hematol. 2006 Jul;81(7):479-83. doi: 10.1002/ajh.20549.
4
Hepcidin independent iron recycling in a mouse model of β-thalassaemia intermedia.中间型β地中海贫血小鼠模型中不依赖铁调素的铁循环
Br J Haematol. 2016 Oct;175(2):308-317. doi: 10.1111/bjh.14206. Epub 2016 Jul 13.
5
Analysis of Glycosylation Profiles of Serum Glycoprotein from Iron Overload Thalassemia.铁过载型地中海贫血患者血清糖蛋白糖基化谱分析
Clin Lab. 2018 Jul 1;64(7):1279-1287. doi: 10.7754/Clin.Lab.2018.180319.
6
Iron Status in Newly Diagnosed -Thalassemia Major: High Rate of Iron Status due to Erythropoiesis Drive.新诊断的地中海贫血症患者的铁状态：由于红细胞生成的驱动作用导致铁状态高。
Biomed Res Int. 2021 Apr 16;2021:5560319. doi: 10.1155/2021/5560319. eCollection 2021.
7
Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major.血清铁调素作为重型β地中海贫血严重铁过载的诊断标志物。
Indian J Pediatr. 2017 Oct;84(10):745-750. doi: 10.1007/s12098-017-2375-4. Epub 2017 Jun 10.
8
Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.调节铁调素作为原发性和继发性铁过载疾病的治疗方法：临床前模型与途径
Hematol Oncol Clin North Am. 2014 Apr;28(2):387-401. doi: 10.1016/j.hoc.2013.11.004. Epub 2014 Jan 18.
9
Imbalance of erythropoiesis and iron metabolism in patients with thalassemia.地中海贫血患者的红细胞生成和铁代谢失衡。
Int J Med Sci. 2019 Jan 1;16(2):302-310. doi: 10.7150/ijms.27829. eCollection 2019.
10
Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression.铁负荷增加引起的红细胞生成刺激导致铁调素减少，尽管骨形态发生蛋白 6 的表达增加。
Br J Haematol. 2012 Jun;157(5):615-26. doi: 10.1111/j.1365-2141.2012.09104.x. Epub 2012 Mar 26.
引用本文的文献
1
Incidence of cancer and related deaths in hemoglobinopathies: A follow-up of 4631 patients between 1970 and 2021.血红蛋白病患者的癌症发病率和相关死亡率：1970 年至 2021 年对 4631 例患者的随访研究。
Cancer. 2023 Jan 1;129(1):107-117. doi: 10.1002/cncr.34509. Epub 2022 Nov 2.
2
Thalassemia Intermedia: Chelator or Not?中间型地中海贫血：螯合剂治疗，还是不治疗？
Int J Mol Sci. 2022 Sep 5;23(17):10189. doi: 10.3390/ijms231710189.
3
Phosphatidylserine-exposed red blood cells and ineffective erythropoiesis biomarkers in patients with thalassemia.地中海贫血患者中暴露磷脂酰丝氨酸的红细胞及无效红细胞生成生物标志物
Am J Transl Res. 2022 Jul 15;14(7):4743-4756. eCollection 2022.
4
Iron overload disorders.铁过载疾病。
Hepatol Commun. 2022 Aug;6(8):1842-1854. doi: 10.1002/hep4.2012. Epub 2022 Jun 14.
5
Clinical interpretation of serum hepcidin-25 in inflammation and renal dysfunction.血清铁调素-25在炎症和肾功能不全中的临床解读
J Mass Spectrom Adv Clin Lab. 2022 Mar 28;24:43-49. doi: 10.1016/j.jmsacl.2022.03.002. eCollection 2022 Apr.
6
Novel Therapeutic Advances in β-Thalassemia.β地中海贫血的新型治疗进展
Biology (Basel). 2021 Jun 18;10(6):546. doi: 10.3390/biology10060546.
7
The Interplay between Drivers of Erythropoiesis and Iron Homeostasis in Rare Hereditary Anemias: Tipping the Balance.红细胞生成与铁稳态的相互作用在罕见遗传性贫血中的作用：打破平衡。
Int J Mol Sci. 2021 Feb 23;22(4):2204. doi: 10.3390/ijms22042204.
8
Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis.非输血依赖型地中海贫血伴髓外造血患者的红细胞生成和铁稳态。
Biomed Res Int. 2019 Jan 30;2019:4504302. doi: 10.1155/2019/4504302. eCollection 2019.
9
Imbalance of erythropoiesis and iron metabolism in patients with thalassemia.地中海贫血患者的红细胞生成和铁代谢失衡。
Int J Med Sci. 2019 Jan 1;16(2):302-310. doi: 10.7150/ijms.27829. eCollection 2019.
10
EPO and hepcidin plasma concentrations in blood donors and β-thalassemia intermedia are not related to commercially tested plasma ERFE concentrations.献血者和中间型β地中海贫血患者血浆中促红细胞生成素（EPO）和铁调素的浓度与商业检测的血浆促红细胞生成素红细胞铁结合蛋白（ERFE）浓度无关。
Am J Hematol. 2017 Mar;92(3):E29-E31. doi: 10.1002/ajh.24636.
本文引用的文献
1
Identification of erythroferrone as an erythroid regulator of iron metabolism.鉴定红系铁调素为铁代谢的红系调节因子。
Nat Genet. 2014 Jul;46(7):678-84. doi: 10.1038/ng.2996. Epub 2014 Jun 1.
2
Hepcidin in human iron disorders: diagnostic implications.人铁代谢紊乱中的铁调素：诊断意义。
Clin Chem. 2011 Dec;57(12):1650-69. doi: 10.1373/clinchem.2009.140053. Epub 2011 Oct 11.
3
Serum hepcidin: reference ranges and biochemical correlates in the general population.血清铁调素：普通人群的参考范围和生化相关性。
Blood. 2011 Jun 23;117(25):e218-25. doi: 10.1182/blood-2011-02-337907. Epub 2011 Apr 28.
4
Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders.基于免疫化学和质谱的血清铁调素检测在铁代谢紊乱中的应用。
Clin Chem. 2010 Oct;56(10):1570-9. doi: 10.1373/clinchem.2010.149187. Epub 2010 Aug 25.
5
Hb H disease: clinical course and disease modifiers.Hb H 病：临床病程和疾病修饰因子。
Hematology Am Soc Hematol Educ Program. 2009:26-34. doi: 10.1182/asheducation-2009.1.26.
6
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.在小鼠和人类细胞中鉴定TWSG1作为铁调素表达的第二种新型红细胞调节因子。
Blood. 2009 Jul 2;114(1):181-6. doi: 10.1182/blood-2008-12-195503. Epub 2009 May 4.
7
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.地中海贫血中高水平的生长分化因子15抑制铁调节蛋白铁调素的表达。
Nat Med. 2007 Sep;13(9):1096-101. doi: 10.1038/nm1629. Epub 2007 Aug 26.
8
Liver iron concentrations and urinary hepcidin in beta-thalassemia.β地中海贫血患者的肝脏铁浓度和尿铁调素
Haematologica. 2007 May;92(5):583-8. doi: 10.3324/haematol.10842.
9
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.β地中海贫血中无效造血的特征是，通过铁调素下调和铁转运蛋白上调介导的铁吸收增加。
Blood. 2007 Jun 1;109(11):5027-35. doi: 10.1182/blood-2006-09-048868. Epub 2007 Feb 13.
10
Hepcidin in iron overload disorders.铁过载疾病中的铁调素
Blood. 2005 May 15;105(10):4103-5. doi: 10.1182/blood-2004-12-4844. Epub 2005 Jan 25.
Zotero 插件