Baumann-Vogel H, Valko P O, Eisele G, Baumann C R
Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Eur J Neurol. 2015 Apr;22(4):603-9. doi: 10.1111/ene.12646. Epub 2015 Jan 18.
Impulse control disorders (ICDs) and related conditions in Parkinson's disease (PD) patients are frequent, disabling and sometimes devastating neuropsychiatric behaviors. Current knowledge on the prevalence of ICDs in PD is mainly based on assessments with questionnaires or patient interviews. This study was designed to evaluate the reliability of self-assessed ICDs and related conditions in PD by exploring the agreement between self-assessment of ICDs and related conditions in PD patients on the one hand and the estimation of their caregivers on the other hand.
After a short validation study of a novel ICD screening questionnaire, a cross-sectional study in 150 PD patients was performed. All patients filled out the self-assessment version of a screening questionnaire for ICDs, and caregivers completed an adapted version (n = 64).
When comparing self-assessments of PD patients and ratings by their caregivers, significant differences with regard to the estimated prevalence of hypersexuality (55% vs. 17%), dopamine dysregulation syndrome (31% vs. 3%) and punding (22% vs. 9%) were found.
Patients underestimate the presence and severity of some ICDs and related conditions, which shows how important assessments with caregivers are. After all, ICDs are probably much more frequent in PD than previously reported.
帕金森病（PD）患者的冲动控制障碍（ICD）及相关病症较为常见，会导致残疾，有时甚至是具有毁灭性的神经精神行为。目前关于PD中ICD患病率的认识主要基于问卷调查或患者访谈评估。本研究旨在通过探究PD患者对ICD及相关病症的自我评估与他们的照料者的评估之间的一致性，来评估PD中自我评估的ICD及相关病症的可靠性。
在对一份新型ICD筛查问卷进行简短的验证研究后，对150例PD患者进行了一项横断面研究。所有患者填写了ICD筛查问卷的自我评估版本，照料者完成了一个改编版本（n = 64）。
比较PD患者的自我评估与照料者的评分时，发现性欲亢进（55%对17%）、多巴胺调节障碍综合征（31%对3%）和刻板动作（22%对9%）的估计患病率存在显著差异。
患者低估了一些ICD及相关病症的存在和严重程度，这表明了照料者评估的重要性。毕竟，ICD在PD中的实际发生率可能比之前报道的要高得多。
