蜡样芽孢杆菌和短小芽孢杆菌代谢产物的驱虫活性评估。
Evaluation of Bacillus cereus and Bacillus pumilus metabolites for anthelmintic activity.
作者信息
Kumar M L Vijaya, Thippeswamy B, Kuppust I L, Naveenkumar K J, Shivakumar C K
机构信息
Department of Pharmacognosy, National College of Pharmacy, Shankarghatta, Shimoga, Karnataka, India.
Department of Microbiology, Kuvempu University, Shankarghatta, Shimoga, Karnataka, India.
出版信息
Pharmacognosy Res. 2015 Jan-Mar;7(1):81-4. doi: 10.4103/0974-8490.147213.
OBJECTIVE
To assess the anthelmintic acivity of Bacillus cereus and Bacillus pumilus metabolites.
MATERIALS AND METHODS
The successive solvent extractions with petroleum ether, ethyl acetate and methanol. The solvent extracts were tested for anthelmintic activity against Pheretima posthuma at 20 mg/ml concentration. The time of paralysis and time of death of the worms was determined for all the extracts. Albendazole was taken as a standard reference and sterile water as a control.
RESULTS
All the sample extracts showed significant anthelmintic activity in paralyzing the worms comparable with that of the standard drug. The time of death exhibited by BP metabolites was close to the time exhibited by standard.
CONCLUSION
The study indicates both bacteria Bacillus cereus and Bacillus pumilus have anthelmintic activity indicating potential metabolites in them.
目的
评估蜡样芽孢杆菌和短小芽孢杆菌代谢产物的驱虫活性。
材料与方法
依次用石油醚、乙酸乙酯和甲醇进行溶剂萃取。将溶剂提取物以20mg/ml的浓度测试对参环毛蚓的驱虫活性。测定所有提取物使蠕虫麻痹的时间和死亡时间。以阿苯达唑作为标准对照，无菌水作为对照。
结果
所有样品提取物在使蠕虫麻痹方面均表现出显著的驱虫活性，与标准药物相当。短小芽孢杆菌代谢产物的死亡时间与标准药物相近。
结论
该研究表明蜡样芽孢杆菌和短小芽孢杆菌均具有驱虫活性，表明它们含有潜在的代谢产物。
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