Jabbar Abdul, Iqbal Zafar, Kerboeuf Dominique, Muhammad Ghulam, Khan Muhammad N, Afaq Musarrat
Chemotherapy Laboratory, Department of Veterinary Parasitology, University of Agriculture, Faisalabad-38040, Pakistan.
Life Sci. 2006 Nov 25;79(26):2413-31. doi: 10.1016/j.lfs.2006.08.010. Epub 2006 Aug 17.
Helminthosis is one of the major constraints in the successful wool and mutton industry throughout the world. Anthelmintic Resistance (AR) is said to have been established when previously effective drug ceases to kill exposed parasitic population at the therapeutically recommended dosages. Anthelmintic resistance is almost cosmopolitan in distribution and it has been reported in almost all species of domestic animals and even in some parasites of human beings. Some of the most important species of parasites of small ruminants in which AR has been reported include: Haemonchus spp., Trichostrongylus spp. Teladorsagia spp., Cooperia spp. Nematodirus spp., and Oesophagostomum spp. All the major groups of anthelmintics have been reported for development of variable degrees of resistance in different species of gastrointestinal nematodes. This paper describes the global scenario of prevalence and methods used for detection of AR in small ruminants. Different mechanisms and contributory factors for the development of AR are discussed. Various options and alternate strategies for the control and/or delay in the onset of AR are suggested in the light of available information.
蠕虫病是全球羊毛和羊肉产业成功发展的主要制约因素之一。当先前有效的药物在治疗推荐剂量下无法杀死暴露的寄生虫群体时，就被认为产生了抗蠕虫药耐药性（AR）。抗蠕虫药耐药性几乎遍布全球，几乎在所有家畜物种甚至一些人类寄生虫中都有报道。已报道出现抗蠕虫药耐药性的小型反刍动物一些最重要的寄生虫种类包括：血矛线虫属、毛圆线虫属、细颈线虫属、古柏线虫属、细粒棘球绦虫属和食道口线虫属。所有主要类别的抗蠕虫药都已报道在不同种类的胃肠线虫中产生了不同程度的耐药性。本文描述了小型反刍动物中抗蠕虫药耐药性的全球流行情况及检测方法。讨论了抗蠕虫药耐药性产生的不同机制和促成因素。根据现有信息，提出了控制和/或延缓抗蠕虫药耐药性出现的各种选择和替代策略。
