Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Eur Respir Rev. 2018 Feb 7;27(147). doi: 10.1183/16000617.0110-2017. Print 2018 Mar 31.
Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, "omics" data and bioinformatic computing power. It paves the way forward towards "P4 medicine" (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.
人类健康和疾病是复杂、非线性、动态多层次生物系统（人体）的涌现特性。系统生物学是一种全面的研究策略，有潜力从整体上理解这些涌现特性。它源于医学诊断、“组学”数据和生物信息计算能力的进步。它为“P4 医学”（预测性、预防性、个体化和参与性）铺平了道路，旨在更好地进行预防性干预以保持健康或进行治疗以治愈疾病。在这篇综述中，我们：1）讨论系统生物学的原理；2）详细阐述 P4 医学如何有可能将医疗保健从反应性医学（治疗疾病）转变为预测和预防疾病，这将是一场个性化的、本质上是概率性的和参与性驱动的革命；3）综述网络（系统）医学在三种常见呼吸系统疾病（慢性阻塞性肺疾病、哮喘和肺癌）中的当前现状；4）概述该领域当前的挑战和未来目标。
