Desrosiers R C, Ringler D J
Department of Microbiology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
Intervirology. 1989;30(6):301-12. doi: 10.1159/000150108.
Despite frequent statements to the contrary, there are good animal models for AIDS. In this review, we summarize the properties of one of the most useful animal models: infection of rhesus monkeys with simian immunodeficiency virus (SIV). The SIVs are an extensive group of HIV-related lentiviruses of nonhuman primates. They closely resemble the human AIDS viruses, HIV-1 and HIV-2, in both genetic sequence and biological properties. Some SIV isolates, most notably those derived from macaques and mangabeys, induce AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. Rhesus monkeys are not endangered in the wild, they breed well in captivity, and they are available in reasonably large numbers. Study of SIV has already resulted in seminal contributions regarding the origins of the HIVs, AIDS pathogenesis, and vaccine and therapy research. Continued use of SIV systems will be an important weapon in our arsenal against AIDS.
尽管经常有相反的说法，但确实存在很好的艾滋病动物模型。在这篇综述中，我们总结了最有用的动物模型之一的特性：恒河猴感染猴免疫缺陷病毒（SIV）。SIV是一大类与HIV相关的非人类灵长类慢病毒。它们在基因序列和生物学特性上与人类艾滋病病毒HIV-1和HIV-2极为相似。一些SIV分离株，最显著的是那些源自猕猴和白眉猴的分离株，能在适合实验室研究的时间范围内使恒河猴患上艾滋病。恒河猴在野外并非濒危物种，它们在圈养环境中繁殖良好，且数量相当可观。对SIV的研究已经在HIV的起源、艾滋病发病机制以及疫苗和治疗研究方面做出了开创性贡献。继续使用SIV系统将是我们抗击艾滋病的重要武器。
