视觉识别记忆，表现为长期习惯化，需要 V1 中的突触可塑性。
Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
机构信息
1] The Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
1] The Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [4] Department of Biology, Boston University, Boston, Massachusetts, USA.
出版信息
Nat Neurosci. 2015 Feb;18(2):262-71. doi: 10.1038/nn.3920. Epub 2015 Jan 19.
Familiarity with stimuli that bring neither reward nor punishment, manifested through behavioral habituation, enables organisms to detect novelty and devote cognition to important elements of the environment. Here we describe in mice a form of long-term behavioral habituation to visual grating stimuli that is selective for stimulus orientation. Orientation-selective habituation (OSH) can be observed both in exploratory behavior in an open arena and in a stereotyped motor response to visual stimuli in head-restrained mice. We found that the latter behavioral response, termed a 'vidget', requires V1. Parallel electrophysiological recordings in V1 revealed that plasticity, in the form of stimulus-selective response potentiation (SRP), occurred in layer 4 of V1 as OSH developed. Local manipulations of V1 that prevented and reversed electrophysiological modifications likewise prevented and reversed memory demonstrated behaviorally. These findings suggest that a form of long-term visual recognition memory is stored via synaptic plasticity in primary sensory cortex.
对既无奖励也无惩罚的刺激产生熟悉感，表现在行为习惯化上，使生物体能够察觉新奇事物，并将认知集中在环境的重要元素上。在这里，我们在小鼠中描述了一种对视觉光栅刺激的长期行为习惯化形式，这种形式对刺激方向具有选择性。在开放式竞技场中的探索行为和在头部固定的小鼠对视觉刺激的刻板运动反应中，都可以观察到方向选择性习惯化（OSH）。我们发现，后一种行为反应，称为“vidget”，需要 V1。在 V1 中进行的平行电生理记录显示，随着 OSH 的发展，以刺激选择性反应增强（SRP）的形式发生了可塑性。在 V1 中进行局部操作，防止和逆转电生理改变，同样可以防止和逆转行为表现出的记忆。这些发现表明，长期视觉识别记忆的一种形式通过初级感觉皮层中的突触可塑性来存储。
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