Bonnel Samantha, Berguiga Marouen, De Rivoyre Benoit, Bedubourg Gabriel, Sendon Damien, Froussart-Maille Françoise, Rigal-Sastourne Jean-Claude
J Refract Surg. 2015 Jan;31(1):36-40. doi: 10.3928/1081597X-20141218-04.
To evaluate the visualization and depth of the demarcation line with anterior segment optical coherence tomography (AS-OCT) after iontophoresis-assisted transepithelial corneal collagen cross-linking (CXL).
This prospective, consecutive, single center, non-randomized clinical study involved 15 eyes of 12 patients with keratoconus who underwent an AS-OCT scan (Spectralis; Heidelberg Engineering, Inc., Carlsbad, CA) to search for a demarcation line and its depth at 1 month after iontophoresis-assisted transepithelial CXL. AS-OCT scan measurements were performed by two independent examiners.
No intraoperative or postoperative complications were observed. Kappa coefficient estimation for operator agreement in demarcation line visualization (whether it was visualized) was 70.6%. The corneal stromal demarcation line was identified in 9 eyes (60%) by both examiners. Mean depth of the corneal stromal demarcation line was 246.67 ± 50.72 µm (range: 183 to 339 µm) for the first examiner and 241.89 ± 62.52 µm (range: 163 to 358 µm) for the second examiner. There were no statistically significant differences for the measurements of the paired comparisons between the two examiners (P = .61). The Pearson correlation coefficient between the measurements was 0.910.
Iontophoresis-assisted transepithelial CXL creates a demarcation line that can be visualized with AS-OCT, which seems less easily distinguishable and shallower than in conventional CXL. However, its depth and visualization seems to be more similar to conventional CXL than transepithelial CXL.
评估离子电渗辅助经上皮角膜胶原交联术（CXL）后，眼前节光学相干断层扫描（AS - OCT）对分界线的可视化情况及深度。
这项前瞻性、连续性、单中心、非随机临床研究纳入了12例圆锥角膜患者的15只眼，这些患者在离子电渗辅助经上皮CXL术后1个月接受了AS - OCT扫描（Spectralis；海德堡工程公司，加利福尼亚州卡尔斯巴德），以寻找分界线及其深度。AS - OCT扫描测量由两名独立的检查者进行。
未观察到术中或术后并发症。检查者在分界线可视化（是否能看到）方面的一致性kappa系数估计为70.6%。两名检查者在9只眼（60%）中均识别出角膜基质分界线。第一位检查者测得的角膜基质分界线平均深度为246.67±50.72µm（范围：183至339µm），第二位检查者测得的为241.89±62.52µm（范围：163至358µm）。两名检查者的配对比较测量结果无统计学显著差异（P = 0.61）。测量值之间的Pearson相关系数为0.910。
离子电渗辅助经上皮CXL会产生一条可通过AS - OCT可视化的分界线，它似乎比传统CXL更难区分且更浅。然而，其深度和可视化情况似乎比经上皮CXL更类似于传统CXL。
