Jang M, Son W-G, Lee I
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea.
J Small Anim Pract. 2015 Jun;56(6):411-3. doi: 10.1111/jsap.12312. Epub 2015 Jan 20.
Fentanyl is used in small animals for perioperative analgesia during anaesthesia. Severe bradycardia and asystole were observed on bolus administration of a 3 µg/kg loading dose of fentanyl in two dogs under isoflurane anaesthesia. Premedication with 10 µg/kg glycopyrrolate did not prevent asystole in the first case; and although bradycardia was treated with 5 µg/kg glycopyrrolate administered intravenously in the second case, the heart rate continuously decreased and asystole subsequently developed. Asystole in both cases was quickly corrected by intravenous administration of 0 · 04 mg/kg atropine and closed chest compressions. This case report describes asystole induced by fentanyl administration in isoflurane anaesthetised dogs. Atropine was more effective than glycopyrrolate in the treatment of fentanyl-induced asystole.
芬太尼用于小动物麻醉期间的围手术期镇痛。在异氟烷麻醉下的两只犬中，静脉注射3μg/kg负荷剂量的芬太尼后观察到严重心动过缓和心搏停止。第一例中，术前使用10μg/kg格隆溴铵未能预防心搏停止；第二例中，虽然静脉注射5μg/kg格隆溴铵治疗心动过缓，但心率持续下降，随后发展为心搏停止。两例心搏停止均通过静脉注射0.04mg/kg阿托品和胸外按压迅速纠正。本病例报告描述了异氟烷麻醉犬中芬太尼给药诱发的心搏停止。在治疗芬太尼诱发的心搏停止方面，阿托品比格隆溴铵更有效。
