Akman Levent, Sahin Gulnaz, Erbas Oytun, Aktug Huseyin, Akdogan Aysin, Goker Ege Nazan Tavmergen, Taskiran Dilek, Tavmergen Erol
Department of Obstetrics and Gynecology, Ege University Medical School , Izmir , Turkey .
Gynecol Endocrinol. 2015 May;31(5):369-73. doi: 10.3109/09513590.2014.1000849. Epub 2015 Jan 20.
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication that can occur during assisted reproductive techniques. The aim of this study is to investigate the effects of the leukotriene receptor antagonist (montelukast) treatment in prevention of OHSS and compare to cabergoline treatment. Twenty-four immature female Wistar rats were assigned to four groups. Group 1 was the control group. In the remaining three groups, OHSS was induced through ovarian stimulation with gonadotropins. No treatment was given to Group 2. Group 3 was administered a low-dose 100 mg/kg cabergoline treatment and Group 4 was received 20 mg/kg montelukast. Body weight, ovarian weight, vasculary permability (VP), peritoneal fluid vascular endothelial growth factor (VEGF) values and VEGF immune-expression were compared between the groups. Both cabergoline and montelukast prevented progression of OHSS compared to the OHSS group. Body weight, ovarian weight, VP, peritoneal fluid VEGF values and VEGF expression were significantly lower in both cabergoline- and montelukast-treated rats than in those not treated OHSS group. In conclusion, montelukast is an effective option for prevention of OHSS, as well as cabergoline. Montelukast may be a new treatment option to prevent and control the OHSS.
卵巢过度刺激综合征（OHSS）是辅助生殖技术过程中可能发生的一种严重医源性并发症。本研究旨在探讨白三烯受体拮抗剂（孟鲁司特）治疗在预防OHSS中的效果，并与卡麦角林治疗进行比较。将24只未成熟雌性Wistar大鼠分为四组。第1组为对照组。在其余三组中，通过促性腺激素刺激卵巢诱导OHSS。第2组未进行治疗。第3组给予低剂量100mg/kg卡麦角林治疗，第4组给予20mg/kg孟鲁司特。比较各组之间的体重、卵巢重量、血管通透性（VP）、腹腔液血管内皮生长因子（VEGF）值和VEGF免疫表达。与OHSS组相比，卡麦角林和孟鲁司特均能预防OHSS的进展。卡麦角林和孟鲁司特治疗的大鼠的体重、卵巢重量、VP、腹腔液VEGF值和VEGF表达均显著低于未治疗的OHSS组。总之，孟鲁司特与卡麦角林一样，是预防OHSS的有效选择。孟鲁司特可能是预防和控制OHSS的一种新的治疗选择。
