Kasap Esin, Turan Gülizar Arzu, Eskicioğlu Fatma, Cengiz Hakan, Gur Esra Bahar, Sivrikoz Oya Nermin, Genc Mine, Yılmaz Osman
a Department of Obstetrics and Gynecology , Sifa University School of Medicine , İzmir , Turkey.
b Department of Obstetrics and Gynecology , Merkez Efendi State Hospital , Manisa , Turkey.
Gynecol Endocrinol. 2016 Aug;32(8):634-640. doi: 10.3109/09513590.2016.1152575. Epub 2016 Mar 3.
The aim of this study is to investigate the effects of resveratrol in a rat model of ovarian hyperstimulation syndrome (OHSS) and compare with cabergoline.
Randomized controlled, animal study.
ANIMAL(S): Female Wistar rats.
A rat OHSS model was used to investigate the effects of resveratrol compare with cabergoline administration for preventing OHSS. Body weight, ovary weight, diameter, vascular permeability (VP), vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) expression (immunohistochemistry), and serum estradiol (E2) levels were then compared.
The ovarian VEGF concentration was significantly increased in the OHSS Groups (Groups 3-5) compared with the control groups (1 and 2). But vascular permeability, VEGF, and COX-2 expressions were reduced in animals treated with the resveratrol group compared with the cabergoline group (group 5) and the severe OHSS (group 3) group. Blood E2 levels were decreased in group treated with the resveratrol group compared with the cabergoline group (group 5) and severe the OHSS (group 3) group.
CONCLUSION(S): Our results in a rat model suggest that resveratrol has a beneficial effect on OHSS by reducing the increases in ovarian daimeter, VP, and VEGF expression associated with OHSS. These effects may be mediated by the COX-2 inhibitory capacity of resveratrol.
本研究旨在探讨白藜芦醇对卵巢过度刺激综合征（OHSS）大鼠模型的影响，并与卡麦角林进行比较。
随机对照动物研究。
雌性Wistar大鼠。
采用大鼠OHSS模型研究白藜芦醇与卡麦角林给药预防OHSS的效果。随后比较体重、卵巢重量、直径、血管通透性（VP）、血管内皮生长因子（VEGF）、环氧合酶-2（COX-2）表达（免疫组织化学）及血清雌二醇（E2）水平。
与对照组（1组和2组）相比，OHSS组（3 - 5组）卵巢VEGF浓度显著升高。但与卡麦角林组（5组）和重度OHSS组（3组）相比，白藜芦醇治疗组动物的血管通透性、VEGF和COX-2表达降低。与卡麦角林组（5组）和重度OHSS组（3组）相比，白藜芦醇治疗组血液E2水平降低。
我们在大鼠模型中的结果表明，白藜芦醇通过减少与OHSS相关的卵巢直径、VP和VEGF表达增加，对OHSS具有有益作用。这些作用可能由白藜芦醇的COX-2抑制能力介导。
