Sordillo Peter P, Helson Lawrence
SignPath Pharma, Inc., Quakertown, PA, U.S.A.
In Vivo. 2015 Jan-Feb;29(1):1-4.
The terminal stage of Ebola and other viral diseases is often the onset of a cytokine storm, the massive overproduction of cytokines by the body's immune system.
The actions of curcumin in suppressing cytokine release and cytokine storm are discussed.
Curcumin blocks cytokine release, most importantly the key pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumor necrosis factor-α. The suppression of cytokine release by curcumin correlates with clinical improvement in experimental models of disease conditions where a cytokine storm plays a significant role in mortality.
The use of curcumin should be investigated in patients with Ebola and cytokine storm. Intravenous formulations may allow achievement of therapeutic blood levels of curcumin.
埃博拉病毒病和其他病毒性疾病的终末期通常会引发细胞因子风暴，即机体免疫系统大量过度产生细胞因子。
探讨了姜黄素在抑制细胞因子释放和细胞因子风暴方面的作用。
姜黄素可阻断细胞因子释放，最重要的是关键促炎细胞因子白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α。在细胞因子风暴对死亡率起重要作用的疾病状态实验模型中，姜黄素对细胞因子释放的抑制与临床改善相关。
应研究在埃博拉病毒病和细胞因子风暴患者中使用姜黄素。静脉制剂可能有助于达到姜黄素的治疗血药浓度。
