Ermis Aysegul, Erkiran Murat, Dasdemir Selcuk, Turkcan Ayse Solmaz, Ceylan Mehmet Emin, Bireller Elif Sinem, Cakmakoglu Bedia
Department of Psychiatry, Esenyurt State Hospital, Istanbul, Turkey
Department of Psychiatry, Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital, Istanbul, Turkey.
In Vivo. 2015 Jan-Feb;29(1):129-32.
BACKGROUND/AIM: One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage.
The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele.
The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia.
背景/目的：使用大麻是导致精神障碍增加的风险因素之一。研究表明，多巴胺和其他儿茶酚胺的失活会导致一种常见的多态性，从而使儿茶酚-O-甲基转移酶（COMT）酶活性产生显著变化。我们旨在了解大麻在有无病前使用情况下对精神分裂症病因学的作用。
研究组由80名男性患者组成，通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测COMT酶Val158Met基因多态性的基因分型。
发现病前使用大麻的患者中Val/Val基因型（88.9%）显著高于未病前使用大麻的患者（68.4%）。此外，Val/Val基因型组的平均阳性和阴性症状量表（PANSS）总分显著高于携带Met等位基因的患者得分。
本研究结果证实了COMT Val158 Met多态性与病前使用大麻在导致精神分裂症方面的关联。
