Department of Psychiatry University of Alberta Edmonton AB Canada.
Department of Medicine University of Alberta Edmonton AB Canada.
Brain Behav. 2017 Oct 6;7(11):e00850. doi: 10.1002/brb3.850. eCollection 2017 Nov.
rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.
One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire. DNA was extracted from saliva and genotyping of the Val158Met polymorphism was done by SNaPshot and TaqMan assays. Kaplan-Meier analysis results are reported.
In those who had used cannabis before 20 years of age, rs4680 had a trend level effect on AoP (median AoP: Val/Val < Val/Met < Met/Met 19.37, 20.95, 21.24 years, respectively; log-rank test =.051).
Our data are indicative of the need to further investigate the association between the rs4680 variant and AoP in the context of adolescent cannabis use.
rs4680（Val158Met）基因型调节大麻对精神病发病年龄（AoP）的影响。我们在加拿大白种人样本中，在调整了相关协变量后，调查了 rs4680 与 AoP 之间的关联。
招募了 169 名精神病患者。AoP 定义为 DSM-IV 诊断时的年龄，使用 DSM-IV 结构化临床访谈进行确定。使用自我报告的计算机化问卷收集大麻使用数据。从唾液中提取 DNA，并使用 SNaPshot 和 TaqMan 测定法对 Val158Met 多态性进行基因分型。报告了 Kaplan-Meier 分析结果。
在那些在 20 岁之前使用过大麻的人中，rs4680 对 AoP 有趋势水平的影响（中位 AoP：Val/Val<Val/Met<Met/Met 分别为 19.37、20.95、21.24 岁；对数秩检验 =.051）。
我们的数据表明，需要进一步研究青少年大麻使用背景下 rs4680 变异与 AoP 之间的关联。
