满足社会对新型抗生素的需求：制药行业面临的挑战。
Meeting the societal need for new antibiotics: the challenges for the pharmaceutical industry.
作者信息
O'Brien Seamus
机构信息
Infection Global Medicines Development, AstraZeneca, Macclesfield, Cheshire, UK.
出版信息
Br J Clin Pharmacol. 2015 Feb;79(2):168-72. doi: 10.1111/bcp.12401.
Abstract
The rise of antibiotic resistance is leading to clinicians being increasingly faced with clinical failure due to the lack of effective and safe treatment options. New antibiotics are needed now for current multi-drug resistant infections but also in preparation for emerging and anticipated threats. There are significant challenges for the pharmaceutical industry to discover and develop new antibiotics including a business model that balances reasonable reimbursement with appropriate use. This summary reviews the key challenges and collaborative interventions that may contribute to addressing a societal problem.
摘要
抗生素耐药性的不断上升，导致临床医生越来越多地面临因缺乏有效且安全的治疗选择而出现的临床治疗失败情况。当下，不仅针对当前的多重耐药感染需要新的抗生素，而且为应对新出现的和预期的威胁也需要新抗生素。制药行业在发现和开发新抗生素方面面临重大挑战，包括要建立一种能在合理报销与合理使用之间取得平衡的商业模式。本综述探讨了可能有助于解决这一社会问题的关键挑战和合作干预措施。
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