Liu Min, Chen Meiwan, Xu Ping, Yang Zhiwen
Songjiang Hospital Affiliated Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, 201600, P.R. China.
Curr Pharm Biotechnol. 2015;16(4):313-21. doi: 10.2174/1389201016666150118134805.
Cubosomes are formed by amphiphilic molecules, with the bicontinuous contortions of inter-connecting hydrophilic and hydrophobic domains. The inner cubic-phase structure of cubosomes makes it an attractive drug-delivery system in pharmaceutical applications. This review mainly describes the potential applications of cubosomes as a drug delivery system for oral administration, highlights the mechanisms involved in the transcellular transport and digestive process, challenges involved in formulation development and evaluations of the in vivo and in vitro study. As pointed out throughout this review, a number of critical points on cubosome products need to be solved in order to attain practical applications.
立方液晶由两亲性分子形成，具有相互连接的亲水性和疏水性区域的双连续扭曲结构。立方液晶的内部立方相结构使其成为药物制剂应用中极具吸引力的药物递送系统。本综述主要描述了立方液晶作为口服给药的药物递送系统的潜在应用，强调了跨细胞转运和消化过程中涉及的机制、制剂开发中面临的挑战以及体内和体外研究的评估。正如本综述中所指出的，为了实现实际应用，立方液晶产品的一些关键点需要得到解决。
