Karami Zahra, Hamidi Mehrdad
Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.
Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.
Drug Discov Today. 2016 May;21(5):789-801. doi: 10.1016/j.drudis.2016.01.004. Epub 2016 Jan 15.
Cubosomes are nanostructured liquid crystalline particles, made of certain amphiphilic lipids in definite proportions, known as biocompatible carriers in drug delivery. Cubosomes comprise curved bicontinuous lipid bilayers that are organized in three dimensions as honeycombed structures and divided into two internal aqueous channels that can be exploited by various bioactive ingredients, such as chemical drugs, peptides and proteins. Owing to unique properties such as thermodynamic stability, bioadhesion, the ability of encapsulating hydrophilic, hydrophobic and amphiphilic substances, and the potential for controlled release through functionalization, cubosomes are regarded as promising vehicles for different routes of administration. Based on the most recent reports, this review introduces cubosomes focusing on their structure, preparation methods, mechanism of release and potential routes of administration.
立方液晶纳米粒是由特定比例的某些两亲性脂质构成的纳米结构液晶颗粒，在药物递送中作为生物相容性载体。立方液晶纳米粒由弯曲的双连续脂质双层组成，这些双层在三维空间中排列成蜂窝状结构，并分为两个内部水相通道，各种生物活性成分，如化学药物、肽和蛋白质，可利用这些通道。由于具有热力学稳定性、生物黏附性、包封亲水性、疏水性和两亲性物质的能力以及通过功能化实现控释的潜力等独特性质，立方液晶纳米粒被视为不同给药途径的有前景的载体。基于最新报道，本综述介绍了立方液晶纳米粒，重点关注其结构、制备方法、释放机制和潜在给药途径。
