Cooper B S, Hawk H W
Am J Vet Res. 1978 Apr;39(4):649-52.
Sheep were administered phenobarbital, diphenylhydantoin, chlorcyclizine, or phenylbutazone over 27 days. Rabbits were administered phenobarbital, diphenylhydantoin, or chlorcyclizine for 15 days. After the last treatment, pentobarbital was administered intravenously, and measurements were made of sleep time and blood serum pentobarbital concentrations over a 2-hour period. Treatment of ewes with phenobarbital or phenylbutazone increased the rate of pentobarbital clearance from the circulation and shortened sleep time; treatment with diphenylhydantoin or chlorcyclizine decreased the rates of pentobarbital clearance from blood and increased sleep time. Treatment of rabbits with phenobarbital or diphenylhydantoin accelerated pentobarbital clearance from blood and shortened sleep time; chlorcyclizine had no effect on blood pentobarbital concentrations or sleep time. The results suggest that accelerated or delayed clearance of pentobarbital from the circulation was largely responsible for shortened or prolonged sleep times. Other factors may have been involved to some extent in determining sleep time, because ewes with shortened sleep time tended to awake with lower circulating concentrations of pentobarbital than did control ewes, and those with prolonged sleep time tended to awake with higher pentobarbital values.
绵羊在27天内分别给予苯巴比妥、苯妥英、氯环利嗪或保泰松。兔子在15天内分别给予苯巴比妥、苯妥英或氯环利嗪。在最后一次治疗后，静脉注射戊巴比妥，并在2小时内测量睡眠时间和血清戊巴比妥浓度。用苯巴比妥或保泰松治疗母羊会增加戊巴比妥从循环中的清除率并缩短睡眠时间；用苯妥英或氯环利嗪治疗会降低戊巴比妥从血液中的清除率并延长睡眠时间。用苯巴比妥或苯妥英治疗兔子会加速戊巴比妥从血液中的清除并缩短睡眠时间；氯环利嗪对血液中戊巴比妥浓度或睡眠时间没有影响。结果表明，戊巴比妥从循环中清除的加速或延迟在很大程度上导致了睡眠时间的缩短或延长。在确定睡眠时间方面可能在一定程度上涉及其他因素，因为睡眠时间缩短的母羊醒来时的戊巴比妥循环浓度往往低于对照母羊，而睡眠时间延长的母羊醒来时的戊巴比妥值往往较高。
