Robert J J, Orosco M, Rouch C, Jacquot C, Cohen Y
Laboratoire de Pharmacologie, U.A.CNRS 594, Faculté de Pharmacie, Châtenay-Malabry.
Pharmacol Biochem Behav. 1989 Nov;34(3):577-83. doi: 10.1016/0091-3057(89)90561-3.
The relationship between the effects of opiates on food intake and on central monoamines in various brain areas was investigated in normophagic and obese "cafeteria" rats. Three agonists, beta-endorphin, dynorphin, and D-Ser2-Leu-Enk-Thr6 (DSLET) and an antagonist, naltrexone, were used. The three agonists enhanced feeling in normophagic rats but had different dopaminergic effects. Serotonergic metabolism increased concomitantly with the enhancement of feeding by the agonists, whereas it decreased following treatment with the antagonist naltrexone. In the cafeteria rats, although the feeding effects of dynorphin and DSLET occurred earlier, there was a complete lack of monoaminergic effects. beta-Endorphin was completely devoid of effects in this model. There would, thus, appear to be a positive correlation between the behavioural effects of these opiates and serotonergic metabolism in normophagic rats, while stimulated feeding situations ("cafeteria" rats) the disruption of a monoaminergic modulation does not prohibit a direct effect on feeding.
在正常摄食和肥胖的“自助餐”大鼠中，研究了阿片类药物对食物摄入量的影响与对不同脑区中枢单胺的影响之间的关系。使用了三种激动剂，即β-内啡肽、强啡肽和D-Ser2-Leu-Enk-Thr6（DSLET）以及一种拮抗剂纳曲酮。这三种激动剂增强了正常摄食大鼠的饱腹感，但具有不同的多巴胺能效应。随着激动剂使摄食量增加，5-羟色胺能代谢随之增加，而用拮抗剂纳曲酮治疗后则降低。在“自助餐”大鼠中，尽管强啡肽和DSLET的摄食效应出现得更早，但完全没有单胺能效应。β-内啡肽在该模型中完全没有作用。因此，在正常摄食大鼠中，这些阿片类药物的行为效应与5-羟色胺能代谢之间似乎存在正相关，而在刺激摄食的情况下（“自助餐”大鼠），单胺能调节的破坏并不妨碍对摄食的直接影响。
