Bertiere M C, Sy T M, Baigts F, Mandenoff A, Apfelbaum M
Pharmacol Biochem Behav. 1984 May;20(5):675-9. doi: 10.1016/0091-3057(84)90183-7.
Two experimental situations induce hyperphagia in the rat: the cafeteria model and the tail-pinching model. In non-deprived rats which are offered for one hour a choice of 3 liquid cafeteria items in addition to ordinary chow and water, mild tail-pinching results in a preferential sucrose hyperphagia; naltrexone (2.5 mg/kg IP) suppresses this stress-induced hyperphagia; beta-endorphin (3 micrograms ICV) has the same effect. This apparent discrepancy is discussed: the antagonist may suppress the hyperphagia because it suppresses the reward provoked by the sucrose, the agonist because it makes it unnecessary.
自助餐模型和夹尾模型。在未被剥夺食物的大鼠中，除了普通食物和水之外，给它们提供1小时选择3种液体自助餐食物的机会，轻度夹尾会导致蔗糖优先性食欲亢进；纳曲酮（2.5毫克/千克，腹腔注射）可抑制这种应激诱导的食欲亢进；β-内啡肽（3微克，脑室内注射）也有相同效果。本文讨论了这种明显的差异：拮抗剂可能通过抑制蔗糖引发的奖赏来抑制食欲亢进，而激动剂则可能是通过使其变得不必要来抑制食欲亢进。
