Chowdhury Tumul, Mendelowith David, Golanov Eugene, Spiriev Toma, Arasho Belachew, Sandu Nora, Sadr-Eshkevari Pooyan, Meuwly Cyrill, Schaller Bernhard
*Department of Anesthesiology and Perioperative Medicine, Health Sciences Center, University of Manitoba, Winnipeg, MB, Canada †Department of Pharmacology and Physiology, The George Washington University, Washington, DC ‡Department of Neurosurgery, Houston Methodist Hospital, Houston, TX §Department of Neurosurgery, Tokuda Hospital Sofia, Sofia, Bulgaria ∥Department of Neurology, University of Addis Ababa, Addis Ababa, Ethiopia ¶Department of Research, University of Southampton, Southampton, UK #Professional Program for International Dentists, University of California Los Angeles, CA **University of Basel, Basel, Switzerland.
J Neurosurg Anesthesiol. 2015 Apr;27(2):136-47. doi: 10.1097/ANA.0000000000000065.
The trigeminocardiac reflex (TCR) is defined as the sudden onset of parasympathetic dysrhythmia, sympathetic hypotension, apnea, or gastric hypermotility during stimulation of any of the sensory branches of the trigeminal nerve. Clinically, the TCR has been reported in all the surgical procedures in which a structure innervated by the trigeminal nerve is involved. Although, there is an abundant literature with reports of incidences and risk factors of the TCR; the physiological significance and function of this brainstem reflex has not yet been fully elucidated. In addition, there are complexities within the TCR that requires examination and clarification. There is also a growing need to discuss its cellular mechanism and functional consequences. Therefore, the current review provides an updated examination of the TCR with a particular focus on the mechanisms and diverse nature of the TCR.
三叉神经心脏反射（TCR）的定义为，在刺激三叉神经的任何感觉分支时，突然出现副交感神经节律异常、交感神经低血压、呼吸暂停或胃动力亢进。临床上，在所有涉及三叉神经支配结构的外科手术中均有TCR的报道。尽管有大量文献报道了TCR的发生率和危险因素，但这种脑干反射的生理意义和功能尚未完全阐明。此外，TCR内部存在一些复杂性，需要进行研究和澄清。对其细胞机制和功能后果进行讨论的需求也日益增加。因此，本综述对TCR进行了更新的研究，特别关注TCR的机制和多样性。
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