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Phospholipids: a neuroinflammation emerging target.

作者信息

Kim Hee-Yong

机构信息

National Institute on Alcohol Abuse and Alcoholism, the National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Nat Chem Biol. 2015 Feb;11(2):99-100. doi: 10.1038/nchembio.1740.

DOI:10.1038/nchembio.1740
PMID:25602728
Abstract
摘要

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Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.免疫调节性溶血磷脂酰丝氨酸受ABHD16A和ABHD12相互作用的调控。
Nat Chem Biol. 2015 Feb;11(2):164-71. doi: 10.1038/nchembio.1721. Epub 2015 Jan 12.
2
Phosphatidylserine in the brain: metabolism and function.大脑中的磷脂酰丝氨酸：代谢与功能
Prog Lipid Res. 2014 Oct;56:1-18. doi: 10.1016/j.plipres.2014.06.002. Epub 2014 Jun 30.
3
Novel lysophosphoplipid receptors: their structure and function.新型溶血磷脂受体：其结构与功能
溶血磷脂酰丝氨酸通过非受体依赖方式以正反馈调控的形式诱导气道上皮细胞 TACE-EGFR-ERK 通路诱导 MUC5AC 的产生。
Int J Mol Sci. 2022 Mar 31;23(7):3866. doi: 10.3390/ijms23073866.
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Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines.Mirtronic miR-4646-5p 通过调控 ABHD16A 和代谢物溶血磷脂酰丝氨酸促进胃癌转移。
Cell Death Differ. 2021 Sep;28(9):2708-2727. doi: 10.1038/s41418-021-00779-y. Epub 2021 Apr 19.
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Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.基于计算功能基因组学的 AmpliSeqTM 面板，用于疼痛关键基因的下一代测序。
Int J Mol Sci. 2021 Jan 16;22(2):878. doi: 10.3390/ijms22020878.
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Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A.发现12-噻唑枞酸型二萜类化合物作为人类代谢丝氨酸水解酶hABHD16A的选择性抑制剂。
ACS Med Chem Lett. 2018 Nov 13;9(12):1269-1273. doi: 10.1021/acsmedchemlett.8b00442. eCollection 2018 Dec 13.
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Development of an AmpliSeq Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain.用于对一组持续性疼痛遗传预测因子进行下一代测序的扩增子测序panel的开发。
Front Pharmacol. 2018 Sep 19;9:1008. doi: 10.3389/fphar.2018.01008. eCollection 2018.
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Alcohol Clin Exp Res. 2018 Aug;42(8):1444-1453. doi: 10.1111/acer.13776. Epub 2018 Jun 9.
J Lipid Res. 2014 Oct;55(10):1986-95. doi: 10.1194/jlr.R046920. Epub 2014 Jun 2.
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ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.ABHD12 控制脑中溶血磷脂酰丝氨酸代谢途径，该途径在神经退行性疾病 PHARC 的小鼠模型中失调。
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