GPR39标记皮脂腺内的特定细胞，并有助于皮肤伤口愈合。
GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing.
作者信息
Zhao Huashan, Qiao Jingqiao, Zhang Shoubing, Zhang Huishan, Lei Xiaohua, Wang Xinyue, Deng Zhili, Ning Lina, Cao Yujing, Guo Yong, Liu Shuang, Duan Enkui
机构信息
1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China [2] University of Chinese Academy of Sciences, Beijing, China.
College of Animal Science and Technology, Beijing University of Agriculture, China.
出版信息
Sci Rep. 2015 Jan 21;5:7913. doi: 10.1038/srep07913.
G protein-coupled receptors (GPCRs) mediate multiple key biological processes in the body. The orphan receptor GPR39 has been reported to be involved in various pathophysiological events. However, the function of GPR39 in skin biology remains unknown. Using a genetically engineered mouse strain in which lacZ expression faithfully replaced endogenous Gpr39 expression, we discovered a unique expression pattern of Gpr39 in the sebaceous gland (SG). Using various methods, we confirmed that GPR39 marked a specific cell population at the opening of the SG and colocalised with the SG stem cell marker Blimp1. Further investigations showed that GPR39 was spatiotemporally expressed during skin wound repair. Although it was dispensable for skin development and homeostasis, GPR39 contributed positively to skin wound healing: its loss led to a delay in wound healing during the intermediate stage. The present study reveals a novel role of GPR39 in both dermatology and stem cell biology that has not been previously recognised.
G蛋白偶联受体（GPCRs）介导身体中的多种关键生物学过程。据报道，孤儿受体GPR39参与了各种病理生理事件。然而，GPR39在皮肤生物学中的功能仍然未知。利用一种基因工程小鼠品系，其中lacZ表达忠实地取代了内源性Gpr39表达，我们发现了Gpr39在皮脂腺（SG）中的独特表达模式。使用各种方法，我们证实GPR39标记了SG开口处的特定细胞群，并与SG干细胞标记物Blimp1共定位。进一步的研究表明，GPR39在皮肤伤口修复过程中呈时空表达。虽然它对于皮肤发育和稳态并非必需，但GPR39对皮肤伤口愈合有积极作用：其缺失导致中间阶段伤口愈合延迟。本研究揭示了GPR39在皮肤病学和干细胞生物学中一个以前未被认识到的新作用。
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