Bilgiç Özlem, Bilgiç Ayhan
Department of Dermatology, Faculty of Medicine, Selcuk University, Konya, Turkey.
Atten Defic Hyperact Disord. 2015 Sep;7(3):179-81. doi: 10.1007/s12402-015-0166-1. Epub 2015 Jan 21.
Vitiligo is a chronic skin disease characterized by the appearance of white depigmented lesion due to a loss of melanocytes. The etiopathogenesis of vitiligo is not clear, but according to the neural theory of vitiligo, the direct and indirect effects of monoamine neurotransmitters cause melanocyte destruction and various studies have supported this theory. Many drugs have been related to the development of vitiligo, and the melanocytotoxic effects of the some of these drugs are thought to be related due to their effects on the monoaminergic system. Furthermore, a recent article reported the development of a localized loss of pigmentation after the application of a methylphenidate patch in a patient with attention-deficit/hyperactivity disorder (ADHD). Atomoxetine is an inhibitor of norepinephrine reuptake sites and is a drug that has been used for the treatment of ADHD. Here, we present a school-aged child with ADHD who displayed a vitiligo lesion following the initiation of atomoxetine. We further discuss the possible impact of the ADHD drugs on the development of vitiligo.
白癜风是一种慢性皮肤病，其特征是由于黑素细胞缺失而出现白色色素脱失性皮损。白癜风的病因发病机制尚不清楚，但根据白癜风的神经理论，单胺类神经递质的直接和间接作用会导致黑素细胞破坏，并且各种研究都支持这一理论。许多药物都与白癜风的发生有关，其中一些药物的黑素细胞毒性作用被认为与其对单胺能系统的影响有关。此外，最近一篇文章报道了一名患有注意力缺陷多动障碍（ADHD）的患者在使用哌甲酯贴片后出现局限性色素脱失。托莫西汀是去甲肾上腺素再摄取位点抑制剂，是一种用于治疗ADHD的药物。在此，我们报告一名患有ADHD的学龄儿童，在开始使用托莫西汀后出现了白癜风皮损。我们进一步讨论了ADHD药物对白癜风发生的可能影响。
