单侧右杏仁核或左杏仁核损伤对声音情绪听觉皮层处理的不对称影响。
Asymmetrical effects of unilateral right or left amygdala damage on auditory cortical processing of vocal emotions.
作者信息
Frühholz Sascha, Hofstetter Christoph, Cristinzio Chiara, Saj Arnaud, Seeck Margitta, Vuilleumier Patrik, Grandjean Didier
机构信息
Neuroscience of Emotion and Affective Dynamics Laboratory, Department of Psychology, University of Geneva, 1205 Geneva, Switzerland; Swiss Center for Affective Sciences, University of Geneva, 1211 Geneva, Switzerland;
Swiss Center for Affective Sciences, University of Geneva, 1211 Geneva, Switzerland; Laboratory for Neurology and Imaging of Cognition, Departments of Neurology and Neuroscience, Medical School, University of Geneva, 1211 Geneva, Switzerland; and.
出版信息
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1583-8. doi: 10.1073/pnas.1411315112. Epub 2015 Jan 20.
We tested whether human amygdala lesions impair vocal processing in intact cortical networks. In two functional MRI experiments, patients with unilateral amygdala resection either listened to voices and nonvocal sounds or heard binaural vocalizations with attention directed toward or away from emotional information on one side. In experiment 1, all patients showed reduced activation to voices in the ipsilesional auditory cortex. In experiment 2, emotional voices evoked increased activity in both the auditory cortex and the intact amygdala for right-damaged patients, whereas no such effects were found for left-damaged amygdala patients. Furthermore, the left inferior frontal cortex was functionally connected with the intact amygdala in right-damaged patients, but only with homologous right frontal areas and not with the amygdala in left-damaged patients. Thus, unilateral amygdala damage leads to globally reduced ipsilesional cortical voice processing, but only left amygdala lesions are sufficient to suppress the enhanced auditory cortical processing of vocal emotions.
我们测试了人类杏仁核损伤是否会损害完整皮质网络中的语音处理。在两项功能性磁共振成像实验中，单侧杏仁核切除术患者要么聆听声音和非语音声音，要么听双耳发声，同时将注意力集中在一侧的情感信息上或从该侧转移注意力。在实验1中，所有患者同侧听觉皮层对声音的激活均降低。在实验2中，对于右侧杏仁核受损的患者，情绪化声音在听觉皮层和完整杏仁核中均引起活动增加，而左侧杏仁核受损的患者未发现此类效应。此外，右侧杏仁核受损患者的左下额叶皮质与完整杏仁核存在功能连接，但左侧杏仁核受损患者仅与右侧同源额叶区域存在功能连接，与杏仁核无功能连接。因此，单侧杏仁核损伤会导致同侧皮质语音处理整体减少，但只有左侧杏仁核损伤足以抑制听觉皮层对语音情感的增强处理。
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