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在使用分层皮片进行创面覆盖之前，传统机械固定与在创面床使用自体富血小板血浆（PRP）的比较。

Comparison between Conventional Mechanical Fixation and Use of Autologous Platelet Rich Plasma (PRP) in Wound Beds Prior to Resurfacing with Split Thickness Skin Graft.

作者信息

P Waiker Veena, Shivalingappa Shanthakumar

机构信息

Department of Plastic Surgery, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India.

出版信息

World J Plast Surg. 2015 Jan;4(1):50-9.

DOI:
PMID:25606477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4298865/
Abstract

BACKGROUND: Platelet rich plasma is known for its hemostatic, adhesive and healing properties in view of the multiple growth factors released from the platelets to the site of wound. The primary objective of this study was to use autologous platelet rich plasma (PRP) in wound beds for anchorage of skin grafts instead of conventional methods like sutures, staplers or glue. METHODS: In a single center based randomized controlled prospective study of nine months duration, 200 patients with wounds were divided into two equal groups. Autologous PRP was applied on wound beds in PRP group and conventional methods like staples/sutures used to anchor the skin grafts in a control group. RESULTS: Instant graft adherence to wound bed was statistically significant in the PRP group. Time of first post-graft inspection was delayed, and hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in plastic surgery unit were significantly less in the PRP group. CONCLUSION: Autologous PRP ensured instant skin graft adherence to wound bed in comparison to conventional methods of anchorage. Hence, we recommend the use of autologous PRP routinely on wounds prior to resurfacing to ensure the benefits of early healing.

摘要

背景：鉴于血小板释放到伤口部位的多种生长因子，富含血小板血浆以其止血、黏附和愈合特性而闻名。本研究的主要目的是在伤口床使用自体富含血小板血浆（PRP）来固定皮肤移植，而非使用缝线、吻合器或胶水等传统方法。 方法：在一项为期9个月的单中心随机对照前瞻性研究中，200例伤口患者被分为两组，每组人数相等。PRP组在伤口床应用自体PRP，对照组则使用吻合器/缝线等传统方法固定皮肤移植。 结果：PRP组移植片即刻与伤口床的黏附具有统计学意义。PRP组首次移植后检查时间延迟，且血肿、移植片水肿、移植部位渗液、换药频率及在整形外科病房的住院时间均显著减少。 结论：与传统固定方法相比，自体PRP可确保移植片即刻黏附于伤口床。因此，我们建议在创面修复前常规对伤口使用自体PRP，以确保早期愈合的益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/70315cdd3b66/wjps-4-050-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/08e826d08a5e/wjps-4-050-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/69d773683ebd/wjps-4-050-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/0afe620c5e7a/wjps-4-050-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/80ec782b194a/wjps-4-050-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/a82cfc63ace0/wjps-4-050-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/0da1428f1abd/wjps-4-050-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/08c2be5a36d9/wjps-4-050-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/201268dc9cbe/wjps-4-050-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/36cd893b6e56/wjps-4-050-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/7f7fa3969e39/wjps-4-050-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/26494c49766a/wjps-4-050-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/3243154e0f87/wjps-4-050-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/e3f259dcd1ca/wjps-4-050-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/70315cdd3b66/wjps-4-050-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/08e826d08a5e/wjps-4-050-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/69d773683ebd/wjps-4-050-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/0afe620c5e7a/wjps-4-050-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/80ec782b194a/wjps-4-050-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/a82cfc63ace0/wjps-4-050-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/0da1428f1abd/wjps-4-050-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/08c2be5a36d9/wjps-4-050-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/201268dc9cbe/wjps-4-050-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/36cd893b6e56/wjps-4-050-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/7f7fa3969e39/wjps-4-050-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/26494c49766a/wjps-4-050-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/3243154e0f87/wjps-4-050-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/e3f259dcd1ca/wjps-4-050-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/507a/4298865/70315cdd3b66/wjps-4-050-g014.jpg

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[4]
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BMC Surg. 2024-7-3

[5]
Efficacy of platelet-rich plasma in alleviating split skin graft morbidities.

J Cutan Aesthet Surg. 2024

[6]
Efficiency of platelet-rich plasma in the management of burn wounds: A meta-analysis.

Int Wound J. 2023-9-30

[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
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[2]
The Healing Effects of Aquatic Activities and Allogenic Injection of Platelet-Rich Plasma (PRP) on Injuries of Achilles Tendon in Experimental Rat.

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Foot Ankle Spec. 2008-6

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