Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Internal Medicine, Xi Yuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Int Wound J. 2020 Dec;17(6):1650-1658. doi: 10.1111/iwj.13445. Epub 2020 Jul 7.
Existing evidence demonstrated that the role of platelet-rich plasma (PRP) in skin graft enrichment is uncertain. The aim of this study was to evaluate the efficacy and safety of PRP for skin graft. PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for randomised controlled trials that compared outcomes of skin graft treated with PRP versus those treated with blank controls. The outcomes mainly included the rate of skin graft take, number of skin graft loss and haematoma formation, and complications. There were 11 studies involving a total of 910 cases of skin grafts. Compared with the control group, PRP group had a significantly higher rate of skin graft take (mean difference = 5.47%; 95% confidence interval [CI], 2.80%-8.14%; P < .0001), fewer number of skin graft loss (risk ratio [RR] = 0.26; 95% CI, 0.13-0.55; P = .0004) and fewer cases of haematoma formation (RR = 0.24; 95% CI, 0.11-0.54; P = .0006). There was no significant difference in the incidence of complications between two groups. This meta-analysis summarises current evidence and indicates that PRP is a safe and effective adjuvant for skin graft enrichment.
现有证据表明，富血小板血浆（PRP）在皮片移植中的作用尚不确定。本研究旨在评估 PRP 用于皮片移植的疗效和安全性。检索了 PubMed、EMBASE、Web of Science 和 Cochrane Library 数据库中比较 PRP 处理与空白对照处理的皮片移植结局的随机对照试验。主要结局包括皮片移植成活率、皮片丢失数和血肿形成率以及并发症。共有 11 项研究涉及 910 例皮片移植。与对照组相比，PRP 组皮片移植成活率显著提高（均数差=5.47%；95%置信区间[CI]：2.80%-8.14%；P<.0001），皮片丢失数减少（风险比[RR]=0.26；95%CI：0.13-0.55；P=0.0004），血肿形成减少（RR=0.24；95%CI：0.11-0.54；P=0.0006）。两组并发症发生率无显著差异。本荟萃分析总结了现有证据，表明 PRP 是一种安全有效的皮片移植强化辅助剂。
