Imam Mohamed S, Alotaibi Amjad Abdullah S, Alotaibi Norah Obaid M, Alosaimi Nujud Saud, Alotaibi Shroog Ghazi M, Abdelrahim Mohamed E A
Pharmacy Practice Department, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Clinical Pharmacy Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Int Wound J. 2023 Sep 30;21(2). doi: 10.1111/iwj.14419.
The meta-analysis aimed to assess the efficiency of platelet-rich plasma (PRP) in the management of burn wounds (BWs). Using dichotomous or contentious random- or fixed-effects models, the outcomes of this meta-analysis were examined and the odds ratio (OR) and the mean difference (MD) with 95% confidence intervals (CIs) were computed. Thirteen examinations from 2009 to 2023 were enrolled for the present meta-analysis, including 808 individuals with BWs. PRP had significantly shorter healing time (MD, -5.80; 95% CI, -7.73 to -3.88, p < 0.001), higher healing rate (OR, 3.14; 95% CI, 2.05-4.80, p < 0.001), higher healed area percent (MD, 12.67; 95% CI, 9.79-15.55, p < 0.001) and higher graft take area percent (MD, 4.39; 95% CI, 1.51-7.26, p = 0.003) compared with standard therapy in patients with BW. However, no significant difference was found between PRP and standard therapy in graft take ratio (OR, 1.70; 95% CI, 0.86-3.34, p = 0.13) and infection rate (OR, 0.55; 95% CI, 0.20-1.47, p = 0.23) in patients with BW. The examined data revealed that PRP had a significantly shorter healing time, a higher healing rate, a higher healed area percent and a higher graft take area percent; however, no significant difference was found in graft take ratio or infection rate compared with standard therapy in patients with BW. Yet, attention should be paid to its values since all of the selected examinations had a low sample size and some comparisons had a low number of selected studies.
这项荟萃分析旨在评估富血小板血浆（PRP）在烧伤创面（BW）治疗中的效果。使用二分法或有争议的随机或固定效应模型，对该荟萃分析的结果进行了检验，并计算了比值比（OR）和95%置信区间（CI）的平均差（MD）。纳入了2009年至2023年的13项研究进行本次荟萃分析，包括808例烧伤创面患者。与烧伤创面患者的标准治疗相比，PRP的愈合时间显著缩短（MD，-5.80；95%CI，-7.73至-3.88，p < 0.001），愈合率更高（OR，3.14；95%CI，2.05 - 4.80，p < 0.001），愈合面积百分比更高（MD，12.67；95%CI，9.79 - 15.55，p < 0.001），移植成活面积百分比更高（MD，4.39；95%CI，1.51 - 7.26，p = 0.003）。然而，在烧伤创面患者中，PRP与标准治疗在移植成活率（OR，1.70；95%CI，0.86 - 3.34，p = 0.13）和感染率（OR，0.55；95%CI，0.20 - 1.47，p = 0.23）方面未发现显著差异。所审查的数据显示PRP的愈合时间显著缩短，愈合率更高，愈合面积百分比更高，移植成活面积百分比更高；然而，与烧伤创面患者的标准治疗相比，在移植成活率或感染率方面未发现显著差异。然而，由于所有入选研究的样本量较小且一些比较的入选研究数量较少，因此应关注其价值。
