Chang Wenguang, Chen Li, Hatch Grant M
a Department of Pharmacology & Therapeutics, Faculty of Health Sciences, University of Manitoba, Manitoba Institute of Child Health, 501C John Buhler Research Center, 715 McDermot Avenue, Winnipeg, MB, R3E 0P4, Canada.
b Department of Pharmacology, Norman Bethune Medical College, Jilin University, Changchun 130021, China.
Biochem Cell Biol. 2015 Oct;93(5):479-86. doi: 10.1139/bcb-2014-0107. Epub 2014 Dec 1.
The incidence of type 2 diabetes is increasing rapidly worldwide, and the development of novel anti-diabetic drugs is emerging. However, most anti-diabetic drugs cannot be used in patients with hepatic dysfunction, renal disease, and heart disease, which makes pharmacological therapy of type 2 diabetes complicated. Despite continued introduction of novel agents, the search for an ideal drug that is useful as both a hypoglycemic agent and to reduce diabetes-related complications remains elusive. Berberine is an isoquinoline alkaloid extract that has shown promise as a hypoglycemic agent in the management of diabetes in animal and human studies. Mechanistic studies have revealed beneficial effects of berberine on diabetes-related complications. Although there have been few clinical reports of the anti-diabetic effects of berberine, little documentation of adverse effects in humans positions it as a potential candidate drug to treat type 2 diabetes. In the present review, the anti-diabetic mechanism of berberine, its effect on diabetes-related complications, and its recent use in human clinical studies is highlighted. In addition, we summarize the different treatments for type 2 diabetes in adults and children.
全球范围内2型糖尿病的发病率正在迅速上升，新型抗糖尿病药物也不断涌现。然而，大多数抗糖尿病药物不能用于肝功能不全、肾病和心脏病患者，这使得2型糖尿病的药物治疗变得复杂。尽管不断有新型药物问世，但寻找一种既能作为降血糖药物又能减少糖尿病相关并发症的理想药物仍然困难重重。黄连素是一种异喹啉生物碱提取物，在动物和人体研究中已显示出作为糖尿病治疗中降血糖药物的潜力。机制研究揭示了黄连素对糖尿病相关并发症的有益作用。虽然关于黄连素抗糖尿病作用的临床报告较少，且关于其在人体中的不良反应记录也很少，但这使其成为治疗2型糖尿病的潜在候选药物。在本综述中，重点介绍了黄连素的抗糖尿病机制、其对糖尿病相关并发症的影响以及其在人体临床研究中的最新应用。此外，我们总结了成人和儿童2型糖尿病的不同治疗方法。
