Tiwari Devkumar D, Thorat Vandana M, Pakale Prathamesh V, Patil Sarika, Chavan Dhanashri
Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus. 2024 Aug 27;16(8):e67974. doi: 10.7759/cureus.67974. eCollection 2024 Aug.
Introduction Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, leading to complications such as dyslipidemia, which increases cardiovascular risks. Current treatments for dyslipidemia often have undesirable side effects. This study aims to evaluate the effects of (), (), and their combination in the ratio of 1:1 on the lipid profile in T2DM-induced Wistar rats. Additionally, the study investigates the potential synergistic effects of these two herbs. Materials and methods Mature albino Wistar rats of both sexes were employed, weighing 150-250 g. Rats were obtained from the Central Animal House of Krishna Institute of Medical Sciences and kept under standard laboratory conditions. The study was conducted per the guidelines set by the Committee for Control and Supervision of Experiments on Animals (CCSEA). T2DM was induced using streptozotocin (STZ) and nicotinamide (NIC). Thirteen groups of rats were formed, including normal control (NC), diabetic control (DC), and various treatment groups received varying dosages of , , their polyherbal combination (PHC), and the conventional medications metformin (MET) and glimepiride (GLI). Lipid profiles were measured, and the data were analyzed using one-way ANOVA, followed by the Tukey-Kramer post-hoc test. Results The study revealed that both and showed statistically significant lipid-lowering effects in diabetic rats. The -treated groups displayed a statistically significant and considerable decrease in total cholesterol (TC) and low-density lipoprotein (LDL) levels compared to the DC group. Similarly, -treated groups also showed statistically significant reduced levels of TC and LDL, along with an increase in high-density lipoprotein (HDL). The PHC of and exhibited enhanced lipid-lowering effects compared to individual treatments. No significant differences in triglyceride (TG) levels were observed among the treatment groups. Conclusion and , individually and in combination, effectively modulate lipid profiles in T2DM rats. Their synergistic effects provide a promising alternative for managing dyslipidemia in diabetic patients. Further research is needed to determine the clinical consequences of these findings.
引言 2型糖尿病（T2DM）是一种慢性代谢紊乱疾病，其特征为胰岛素抵抗和高血糖，会导致血脂异常等并发症，进而增加心血管疾病风险。目前用于治疗血脂异常的药物往往存在不良副作用。本研究旨在评估（）、（）及其1:1组合对T2DM诱导的Wistar大鼠血脂谱的影响。此外，该研究还探究了这两种草药的潜在协同作用。材料与方法 使用体重150 - 250 g的成年白化Wistar大鼠，雌雄不限。大鼠购自克里希纳医学科学研究所中央动物房，并饲养于标准实验室条件下。本研究按照动物实验控制与监督委员会（CCSEA）制定的指南进行。采用链脲佐菌素（STZ）和烟酰胺（NIC）诱导T2DM。将大鼠分为13组，包括正常对照组（NC）、糖尿病对照组（DC）以及各个接受不同剂量的（）、（）、其复方草药组合（PHC）、传统药物二甲双胍（MET）和格列美脲（GLI）的治疗组。测量血脂谱，并使用单因素方差分析对数据进行分析，随后进行Tukey-Kramer事后检验。结果 研究表明，（）和（）在糖尿病大鼠中均显示出具有统计学意义的降脂作用。与DC组相比，接受（）治疗的组总胆固醇（TC）和低密度脂蛋白（LDL）水平有统计学意义的显著降低。同样，接受（）治疗的组TC和LDL水平也有统计学意义的降低，同时高密度脂蛋白（HDL）水平升高。（）和（）的PHC与单独治疗相比，表现出更强的降脂作用。各治疗组之间甘油三酯（TG）水平未观察到显著差异。结论 （）和（）单独及联合使用均能有效调节T2DM大鼠的血脂谱。它们的协同作用为管理糖尿病患者的血脂异常提供了一个有前景的替代方案。需要进一步研究以确定这些发现的临床意义。
