抑制 T 细胞的初始激活：Notch 受体信号转导增强 T 细胞对抗原的敏感性。
Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen.
机构信息
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
出版信息
Immunity. 2015 Jan 20;42(1):6-8. doi: 10.1016/j.immuni.2014.12.026.
PMID:25607451
Abstract
Notch receptors are widely expressed and have recognized functions in thymocytes and mature T cells. In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
摘要
Notch 受体广泛表达，并在胸腺细胞和成熟 T 细胞中具有公认的功能。在本期中，Laky 等人（2015 年）表明 Notch 与 Delta 样配体 4（DLL4）的相互作用可放大初始 T 细胞的启动。
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