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肾细胞癌伴边缘性脑炎所致副肿瘤性幻觉和认知功能减退

Renal Cell Carcinoma Presenting with Paraneoplastic Hallucinations and Cognitive Decline from Limbic Encephalitis.

作者信息

Harrison Joshua W, Cherukuri Ramesh, Buchan Debra

机构信息

Department of Internal Medicine, Upstate Medical University, 750 East Adams St., Syracuse, NY, 13210, USA,

出版信息

J Gen Intern Med. 2015 Jul;30(7):1037-40. doi: 10.1007/s11606-014-3172-7. Epub 2015 Jan 22.

Abstract

We present a 66-year-old woman with 2 months of visual hallucinations, unintentional weight loss, and short-term memory decline, whose clinical presentation and EEG supported a diagnosis of limbic encephalitis. Subsequent evaluation for a paraneoplastic etiology revealed a renal mass, which was resected and identified as clear cell renal carcinoma. The patient's clinical condition improved after resection of the mass. When patients present with incongruous subacute neuropsychiatric symptoms, clinicians should be mindful of paraneoplastic neurological disorders, as early diagnosis and treatment of malignancy may lead to symptomatic improvement.

摘要

我们报告一名66岁女性,有2个月的视幻觉、非故意体重减轻和短期记忆减退,其临床表现和脑电图支持边缘叶脑炎的诊断。随后对副肿瘤病因的评估发现一个肾脏肿块,该肿块被切除并确诊为透明细胞肾细胞癌。肿块切除后患者的临床状况有所改善。当患者出现不协调的亚急性神经精神症状时,临床医生应留意副肿瘤性神经系统疾病,因为恶性肿瘤的早期诊断和治疗可能会使症状改善。

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