Nasreddine Ziad S, Phillips Natalie A, Bédirian Valérie, Charbonneau Simon, Whitehead Victor, Collin Isabelle, Cummings Jeffrey L, Chertkow Howard
Center for Clinical Research, Neurology Service, Hôpital Charles LeMoyne, Quebec, Canada.
J Am Geriatr Soc. 2005 Apr;53(4):695-9. doi: 10.1111/j.1532-5415.2005.53221.x.
To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia.
Validation study.
A community clinic and an academic center.
Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC).
The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD.
Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively).
MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
开发一种10分钟的认知筛查工具（蒙特利尔认知评估，MoCA），以协助一线医生检测轻度认知障碍（MCI），这是一种常进展为痴呆的临床状态。
验证研究。
一个社区诊所和一个学术中心。
94例符合MCI临床标准且有心理测量学指标支持的患者，93例轻度阿尔茨海默病（AD）患者（简易精神状态检查表（MMSE）评分≥17），以及90例健康老年对照者（NC）。
对所有参与者进行MoCA和MMSE测试，并评估这两种测试在检测MCI和轻度AD方面的敏感性和特异性。
采用26分的临界值时，MMSE检测MCI的敏感性为18%，而MoCA检测出90%的MCI受试者。在轻度AD组中，MMSE的敏感性为78%，而MoCA检测出100%。MMSE和MoCA的特异性均极佳（分别为100%和87%）。
MCI作为一个实体正在不断演变且存在一定争议。MoCA是一种简短的认知筛查工具，对检测MMSE表现正常范围内患者目前概念化的MCI具有高敏感性和特异性。
