Manunta P, Melis M G, Soro A, Pazzola A, Troffa C, Motzo S, Pala F, Madeddu P, Tonolo G, Glorioso N
Boll Soc Ital Biol Sper. 1989 Nov;65(11):1009-16.
Red cell membrane Na(+)-K+ transport systems, renin-angiotensin-aldosterone system (RAAS) and atrial natriuretic factor (ANF) were studied in a group of 50 mild essential hypertensive patients (n = 25 for each group) age, sex and blood pressure matched. Na(+)-K+ ATPase and intracellular Na+ (Na+ i) were significantly different between the two groups (p less than 0.01). A slight difference was also seen for the Na(+)-K+ cotransport (p less than 0.05) as a likely consequence of the differences in the methodology of Na+ charge to study its efflux from the red cells in vitro. A negative correlation (r = -0.47, p less than 0.01) was observed between ANF and Na(+)-K+ cotransport suggesting an interrelationship of the two systems in the homeostasis in body fluid and electrolytes.
在一组50例轻度原发性高血压患者（每组n = 25）中，研究了红细胞膜钠钾转运系统、肾素 - 血管紧张素 - 醛固酮系统（RAAS）和心房利钠因子（ANF），这些患者在年龄、性别和血压方面相互匹配。两组之间钠钾ATP酶和细胞内钠（Na+i）存在显著差异（p < 0.01）。钠钾协同转运也有轻微差异（p < 0.05），这可能是由于体外研究红细胞钠流出时钠电荷测量方法不同所致。观察到ANF与钠钾协同转运之间存在负相关（r = -0.47，p < 0.01），提示这两个系统在体液和电解质稳态中存在相互关系。
