Jaschonek K, Steinhilber D, Einsele H, Ehninger G, Roth H J
Medizinische Klinik, Universität Tübingen, Federal Republic of Germany.
Eicosanoids. 1989;2(3):189-90.
The effect of novel azole derivatives (itraconazole and fluconazole) on 5-lipoxygenase activity was examined using human polymorphonuclear leukocytes (PMNL) as the enzyme source. The novel imidazole derivative itraconazole proved to be a potent inhibitor (IC50 2 X 10(-6) M) of 5-lipoxygenase activity. In contrast, fluconazole, an antifungal agent with bistriazole structure, had no effect on the Ca2+ ionophore A 23187-induced formation of 5-lipoxygenase metabolites in PMNL.
