Fu Y L
Zhonghua Yi Xue Za Zhi. 1989 Sep;69(9):493-5, 36.
In the serum and cancer tissue of 155 patients with trophoblastic tumor and in 114 patients with benign or malignant gynecologic tumor, 22 elements (17 trace and 5 major elements) were determined by neutron activation analysis. The serum and tissue level of Cr, the serum Zn level in patients with hydatidiform mole was significantly higher than that of the control group (P less than 0.01). The serum Se level in Patients with invasive mole and choriocarcinoma was lower (less than 1.0 mumol/l), but Cu/Zn ratio was higher (greater than 2.0) in comparison with that of the controls (P less than 0.01). With remission of the disease levels of the essential trace elements went up approaching the normal levels. There was a negative relationship between the serum Zn level and hCG content. The authors point out that the low level of Zn and Se, the high level of Cr may be related to the development of trophoblastic tumors.
采用中子活化分析法对155例滋养细胞肿瘤患者及114例良性或恶性妇科肿瘤患者的血清和癌组织进行了22种元素（17种微量元素和5种常量元素）的测定。葡萄胎患者血清铬水平、血清锌水平显著高于对照组（P＜0.01）。侵蚀性葡萄胎和绒毛膜癌患者血清硒水平较低（＜1.0μmol/L），但铜/锌比值高于对照组（＞2.0）（P＜0.01）。随着病情缓解，必需微量元素水平升高并接近正常水平。血清锌水平与hCG含量呈负相关。作者指出，锌和硒水平低、铬水平高可能与滋养细胞肿瘤的发生有关。
