宫颈癌和子宫肌瘤患者血清及组织中六种微量元素水平及铜/锌比值

Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma.

作者信息

Cunzhi Han, Jiexian Jing, Xianwen Zhao, Jingang Guo, Shumin Zheng, Lili Du

机构信息

Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, People's Republic of China.

出版信息

Biol Trace Elem Res. 2003 Aug;94(2):113-22. doi: 10.1385/BTER:94:2:113.

DOI:10.1385/BTER:94:2:113

PMID:12958402

Abstract

The aim of this study is to investigate the relationship between trace elements and the incidence of cervical cancer. Tissue and serum levels of six elements (Cu, Zn, Fe, Mn, Ca, and Se) and the Cu/Zn ratio in 40 cases of patients with cervical cancer, 30 cases of uterine myoma, and 50 healthy subjects were measured by atomic absorption spectrophotometry; the selenium content was determined by atomic fluorescence spectrometry. The results showed that the tissue contents of Zn, Se, and Ca were significantly lower and the Cu and Fe concentrations and Cu/Zn ratio were significantly higher in cervical cancer tissue than that for paired nonlesion tissue (p<0.02 and p<0.001, respectively). The serum levels of Zn, Se, Ca, and Fe were lower and Cu and Mn levels and Cu/Zn ratio were higher in patients with cervical cancer than in healthy subjects (p<0.01 and p<0.001, respectively) and in the uterine myoma group compared with healthy subjects (p<0.05-0.001). There are no significant differences in the contents of six elements and the Cu/Zn ratio between uterine myoma tissue and paired nonlesion tissue. The results showed also that the Fe level and Cu/Zn ratio were significantly higher and the Zn and Se levels were significantly lower in cervical cancer tissue than in uterine myoma tissue (p<0.01 and p<0.001, respectively). The serum Cu level and Cu/Zn ratio were significantly higher in the cervical cancer group than the uterine myoma group (p<0.01). Data were also analyzed using multivarate logistic regression. After adjustment for age, occupation, life habit, and other covariates for the development of cervical cancer, the odds ratios were 22.64 (95% confidence interval [CI]: 5.64-90.88, p=0.001) for Cu, 0.11 (95% CI: 0.034-0.373; p=0.005) for Zn, and 0.60 (95% CI: 0.36-0.99, p=0.01) for Se. Thus, the serum and tissue levels of Cu increase and the deficiency of Zn and Se may be risk factors for the development of cervical cancer.

摘要

本研究旨在探讨微量元素与宫颈癌发病率之间的关系。采用原子吸收分光光度法测定了40例宫颈癌患者、30例子宫肌瘤患者及50例健康对照者六种元素（铜、锌、铁、锰、钙和硒）的组织和血清水平以及铜/锌比值；采用原子荧光光谱法测定硒含量。结果显示，宫颈癌组织中锌、硒和钙的组织含量显著降低，铜、铁浓度及铜/锌比值显著高于配对的非病变组织（分别为p<0.02和p<0.001）。宫颈癌患者血清中锌、硒、钙和铁水平较低，铜、锰水平及铜/锌比值高于健康对照者（分别为p<0.01和p<0.001），与子宫肌瘤组相比也高于健康对照者（p<0.05 - 0.001）。子宫肌瘤组织与配对的非病变组织六种元素含量及铜/锌比值无显著差异。结果还显示，宫颈癌组织中铁水平及铜/锌比值显著高于子宫肌瘤组织，锌和硒水平显著低于子宫肌瘤组织（分别为p<0.01和p<0.001）。宫颈癌组血清铜水平及铜/锌比值显著高于子宫肌瘤组（p<0.01）。数据还采用多变量逻辑回归进行分析。在对年龄、职业、生活习惯及其他宫颈癌发生的协变量进行校正后，铜的比值比为22.64（95%置信区间[CI]：5.64 - 90.88，p = 0.001），锌为0.11（95% CI：0.034 - 0.373；p = 0.005），硒为0.60（95% CI：0.36 - 0.99，p = 0.01）。因此，血清和组织中铜水平升高以及锌和硒缺乏可能是宫颈癌发生的危险因素。