[涉及口服抗癌药物的药代动力学相互作用机制]
[Mecanisms of pharmacokinetic interactions involving oral anticancer agents].
作者信息
Levêque Dominique, Duval Céline, Poulat Charlotte, Palas Benjamin, El Aatmani Anne, Dory Anne, Becker Guillaume, Gourieux Bénédicte
机构信息
Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.
出版信息
Bull Cancer. 2015 Jan;102(1):65-72. doi: 10.1016/j.bulcan.2014.11.001. Epub 2014 Dec 29.
Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.
口服抗癌药物，尤其是激酶抑制剂，在吸收和消除阶段会发生药代动力学药物相互作用。相互作用的因素包括食物、果汁、香烟烟雾、抑酸剂以及诱导剂/抑制剂。一些抗癌药物本身就是诱导剂和/或抑制剂，也会引发药物相互作用。本综述重点阐述了涉及口服抗癌药物的药代动力学药物相互作用机制。
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