Division of Paediatric Oncology, Catholic University of Rome-A. Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, Italy.
Eur J Clin Pharmacol. 2012 Feb;68(2):115-22. doi: 10.1007/s00228-011-1102-8. Epub 2011 Jul 28.
The number of oral anticancer agents has greatly increased in recent years. It is a well-known fact that food intake can induce significant variations in the bioavailability of these drugs. The aim of this review is to describe the interactions between diet and oral anticancer drugs in terms of the possible effects of such interactions on reducing the antineoplastic activity of the drug or increasing its side effects.
This was an analytical study of the numerous mechanisms leading to changes in the bioavailability of oral antineoplastic agents due to diet.
Food-drug interactions can induce a delay, decrease or increase in the absorption of the oral chemotherapeutic agent. The concomitant intake of food and antineoplastic drugs influence the pharmacokinetic and pharmacodynamic drug processes depending on the composition of the food consumed and the specific interactions of the food with transport mechanisms (p-glycoprotein, multidrug resistance proteins) and intestinal enzymatic systems (cytochrome P450).
In prescribing an oral anticancer agent, clinicians must consider the possibility that the consumption of specific food items has the potential to interfere with the pharmacokinetics and pharmacodynamics of the prescribed drug.
近年来，口服抗癌药物的数量大大增加。众所周知，食物的摄入会导致这些药物的生物利用度发生显著变化。本综述的目的是描述饮食与口服抗癌药物之间的相互作用，以及这些相互作用可能对降低药物的抗肿瘤活性或增加其副作用的影响。
这是对由于饮食导致口服抗肿瘤药物生物利用度变化的众多机制的分析研究。
食物-药物相互作用可导致口服化疗药物的吸收延迟、减少或增加。食物和抗肿瘤药物的同时摄入会影响药物的药代动力学和药效学过程，这取决于所摄入的食物的组成以及食物与转运机制（p-糖蛋白、多药耐药蛋白）和肠道酶系统（细胞色素 P450）的特定相互作用。
在开具口服抗癌药物时，临床医生必须考虑到特定食物的摄入有可能干扰所开药物的药代动力学和药效学。
