Nikaido T, Ohmoto T, Kinoshita T, Sankawa U, Delle Monache F, Botta B, Tomimori T, Miyaichi Y, Shirataki Y, Yokoe I
Chem Pharm Bull (Tokyo). 1989 May;37(5):1392-5. doi: 10.1248/cpb.37.1392.
Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated.