Saccomani G, Hersey S J
Department of Physiology and Biophysics, University of Alabama, Birmingham 35294.
Drug Metabol Drug Interact. 1989;7(2-3):161-89. doi: 10.1515/dmdi.1989.7.2-3.161.
In this review consideration is given to anti-ulcer drugs interaction with the gastric H(+)-K+ ATPase. The review has been divided into three sections. First, properties of the gastric proton pump are described in terms of structure, biological activity and ions transport activity, followed by an account of interactions involving antisecretory agents. Emphasis is given to a new class of drugs (substituted benzimidazole) that shows a unique antisecretory action and is safe and effective for short-term treatment of patients with duodenal or gastric ulcers. The final section briefly examines future directions for the production of more selective inhibitors of the gastric proton pump.
本综述探讨了抗溃疡药物与胃H(+)-K+ ATP酶的相互作用。该综述分为三个部分。首先，从结构、生物活性和离子转运活性方面描述了胃质子泵的特性，接着阐述了涉及抗分泌药物的相互作用。重点介绍了一类新型药物（取代苯并咪唑），它具有独特的抗分泌作用，对十二指肠溃疡或胃溃疡患者的短期治疗安全有效。最后一部分简要探讨了生产更具选择性的胃质子泵抑制剂的未来方向。
