Pediatric Unit, Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Giovanni XXIII Hospital, Via Amendola 270, 70126 Bari, Italy.
Laboratory of Experimental Physiopathology, IRCCS, Via F. Valente 4, 70013 Castellana Grotte, Italy.
Benef Microbes. 2015;6(2):195-8. doi: 10.3920/BM2014.0078.
Infantile colic, gastro-oesophageal reflux and constipation are the most common functional gastrointestinal disorders (FGIDs) affecting infants during the first months of life. Despite infantile colic, functional constipation and regurgitation had a self-limited pattern, they are considered a risk factor for developing different disorders later in life. The pathophysiology of these functional diseases is still controversial but there is growing evidence that an abnormal gut microbiota colonisation may play a crucial role. An early probiotic supplementation could determine a change in colonisation and may represent a new strategy for preventing FGIDs.
婴儿绞痛、胃食管反流和便秘是影响婴儿生命最初几个月的最常见功能性胃肠疾病（FGIDs）。尽管婴儿绞痛、功能性便秘和反流具有自限性模式，但它们被认为是以后生活中发生不同疾病的危险因素。这些功能性疾病的病理生理学仍存在争议，但越来越多的证据表明异常肠道微生物定植可能起着关键作用。早期益生菌补充可能会改变定植，并可能代表预防 FGIDs 的新策略。
