dslice：一个用于关联非参数检验的R软件包，应用于数量性状基因座和基因集分析。
dslice: an R package for nonparametric testing of associations with application in QTL and gene set analysis.
作者信息
Ye Chao, Jiang Bo, Zhang Xuegong, Liu Jun S
机构信息
MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China, Department of Statistics, Harvard University, Cambridge, MA 02138, USA, School of Life Sciences, Tsinghua University, Beijing 100084, China and Center of Statistics, Tsinghua University, Beijing 100084, China.
MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China, Department of Statistics, Harvard University, Cambridge, MA 02138, USA, School of Life Sciences, Tsinghua University, Beijing 100084, China and Center of Statistics, Tsinghua University, Beijing 100084, China MOE Key Laboratory of Bioinformatics, Bioinformatics Division and Center for Synthetic & Systems Biology, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China, Department of Statistics, Harvard University, Cambridge, MA 02138, USA, School of Life Sciences, Tsinghua University, Beijing 100084, China and Center of Statistics, Tsinghua University, Beijing 100084, China.
出版信息
Bioinformatics. 2015 Jun 1;31(11):1842-4. doi: 10.1093/bioinformatics/btv021. Epub 2015 Jan 20.
UNLABELLED
Many statistical problems in bioinformatics and genetics can be formulated as the testing of associations between a categorical variable and a continuous variable. A dynamic slicing method was proposed for non-parametric dependence testing, which has been demonstrated to have higher powers compared with traditional methods such as Kolmogorov-Smirnov test. We introduce an R package dslice to facilitate the use of dynamic slicing method in bioinformatic applications such as quantitative trait loci study and gene set enrichment analysis.
AVAILABILITY AND IMPLEMENTATION
dslice is implemented in Rcpp and available in the Comprehensive R Archive Network. The package is distributed under the GNU General Public License (version 2 or later).
未标注
生物信息学和遗传学中的许多统计问题都可以表述为分类变量与连续变量之间关联的检验。提出了一种用于非参数依赖性检验的动态切片方法，与传统方法（如柯尔莫哥洛夫-斯米尔诺夫检验）相比，该方法已被证明具有更高的功效。我们引入了一个R包dslice，以促进动态切片方法在生物信息学应用（如数量性状基因座研究和基因集富集分析）中的使用。
可用性和实现
dslice用Rcpp实现，可在综合R存档网络中获取。该包根据GNU通用公共许可证（版本2或更高版本）分发。
Zotero 插件