Modestin J, Petrin A
Int J Clin Pharmacol Biopharm. 1976 Jan;13(1):11-21.
Results of investigations concerning the correlation between plasma concentrations and clinical effect of neuroleptics and antidepressives are summarised. In the case of neuroleptics there is in general no relationship between clinical parameters of activity and plasma concentration. For antidepressives there is, in most cases, a correlation between side-effects and plasma concentrations. Whether the therapeutic effect is dependent on the plasma concentration or not, is however open to some doubt. The practical value of plasma concentration estimations during therapy with the above mentioned drugs is therefore limited. Inadequate efficacy and/or poor tolerance can occasionally be explained by estimating plasma concentrations which alone, however, scarcely allow one to make prophecies. In determination of the optimal individual dosage must continue to be an empirical process based on clinical observations and experience.
总结了关于抗精神病药和抗抑郁药血浆浓度与临床疗效之间相关性的研究结果。就抗精神病药而言，活性的临床参数与血浆浓度之间通常没有关系。对于抗抑郁药，在大多数情况下，副作用与血浆浓度之间存在相关性。然而，治疗效果是否取决于血浆浓度尚存在一些疑问。因此，在使用上述药物治疗期间估计血浆浓度的实际价值有限。疗效不足和/或耐受性差偶尔可以通过估计血浆浓度来解释，但仅凭血浆浓度几乎无法进行预测。确定最佳个体剂量必须继续是一个基于临床观察和经验的经验性过程。
