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本文引用的文献

1
Cardiac tests in asymptomatic type 2 diabetics.无症状2型糖尿病患者的心脏检查
Med Princ Pract. 2002 Oct-Dec;11(4):171-5. doi: 10.1159/000065818.
2
Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease.在无症状糖尿病且无已知冠状动脉疾病患者中，通过负荷99m锝-甲氧基异丁基异腈心肌灌注单光子发射计算机断层扫描检测到的灌注缺损的患病率及预后价值。
Am J Cardiol. 2002 Oct 15;90(8):827-32. doi: 10.1016/s0002-9149(02)02702-9.
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Detection of myocardial ischemia in patients with diabetes mellitus.
Circulation. 2002 Jan 1;105(1):5-7.
4
Use of dobutamine stress echocardiography in detecting silent myocardial ischaemia in asymptomatic diabetic patients: a comparison with thallium scintigraphy and exercise testing.多巴酚丁胺负荷超声心动图在检测无症状糖尿病患者隐匿性心肌缺血中的应用：与铊闪烁扫描法及运动试验的比较
Diabet Med. 2001 Nov;18(11):900-5. doi: 10.1046/j.1464-5491.2001.00599.x.
5
Detection of coronary artery disease by stress thallium scintigraphy in diabetic patients.
Nucl Med Commun. 2001 Mar;22(3):287-9. doi: 10.1097/00006231-200103000-00005.
6
Prediction of major coronary events by coronary risk profile and silent myocardial ischaemia: prospective follow-up study of primary prevention in 72 diabetic patients.通过冠状动脉风险概况和无症状心肌缺血预测主要冠状动脉事件：72例糖尿病患者一级预防的前瞻性随访研究
Diabetes Metab. 2001 Feb;27(1):49-57.
7
Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia.心脏自主神经病变在合并或不合并无症状心肌缺血的糖尿病患者中的预测价值。
Diabetes Care. 2001 Feb;24(2):339-43. doi: 10.2337/diacare.24.2.339.
8
High incidence of silent myocardial ischemia in elderly patients with non insulin-dependent diabetes mellitus.
Diabetes Res Clin Pract. 2000 Jan;47(1):37-44. doi: 10.1016/s0168-8227(99)00102-3.
9
Silent myocardial ischemia in patients with diabetes: who to screen.糖尿病患者的无症状心肌缺血：筛查对象
Diabetes Care. 1999 Sep;22(9):1396-400. doi: 10.2337/diacare.22.9.1396.
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Gated SPECT imaging.
Semin Nucl Med. 1999 Jul;29(3):271-8. doi: 10.1016/s0001-2998(99)80015-4.

锝-99m甲氧基异丁基异腈门控心肌灌注单光子发射计算机断层显像在2型糖尿病无症状患者无症状性心肌缺血检测中的诊断价值

The Diagnostic Value of Tc-99m MIBI Gated Myocardial Perfusion SPECT in Detection of Silent Myocardial Ischemia in Asymptomatic Patients with Type 2 Diabetes Mellitus.

作者信息

Ak Coskun, Sahin Ali, Capoglu Ilyas

机构信息

Department of Nuclear Medicine, Av. Cengiz Gokcek Hospital, Gaziantep, Turkey.

Department of Nuclear Medicine, Medical School, Ataturk University, Erzurum, Turkey.

出版信息

Eurasian J Med. 2008 Aug;40(2):62-7.

PMID:25610029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4261682/
Abstract

OBJECTIVE

In this study, we aimed to evaluate the diagnostic value of Technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) gated myocardial perfusion SPECT (MPS) in the detection of coronary artery disease (CAD) and silent myocardial ischemia (SMI) in patients with asymptomatic type 2 diabetes mellitus (DM).

MATERIALS AND METHODS

For this purpose, 35 patients with type 2 DM and 15 volunteers with no cardiac symptoms (control group) were included in this study. Exercise tolerance tests (ETT), echocardiography and Tc-99m MIBI gated MPS were performed in patients and volunteers. Computed tomography coronary angiography (CTCA) was performed in patients with coronary ischemia or infarct detected by Tc-99m MIBI gated MPS. The results were analyzed and compared visually and statistically.

RESULTS

The present study revealed a high rate of silent myocardial ischemia (25.71%, N=9) in 35 patients with type 2 DM. Severe CAD in CTCA was detected in four of nine patients with ischemia or infarct by Tc-99m MIBI gated MPS (44.4%). Left ventricular diastolic dysfunction, ischemic pattern and high risk of CAD were detected in the same four patients by echocardiography, ETT and biochemical analysis, respectively. At the end of the statistical evaluation, we found that Tc-99m MIBI gated MPS showed significant correlations with CTCA, echocardiography, ETT, Hba1c level, risk of CAD and diabetic age in diabetic patients with CAD.

CONCLUSION

We propose that Tc-99m MIBI gated MPS is a reliable and non-invasive method that can be used to detect silent myocardial ischemia and CAD in patients with type 2 DM.

摘要

目的

在本研究中，我们旨在评估锝-99m 甲氧基异丁基异腈（Tc-99m MIBI）门控心肌灌注单光子发射计算机断层扫描（MPS）在检测无症状 2 型糖尿病（DM）患者冠状动脉疾病（CAD）和无症状心肌缺血（SMI）方面的诊断价值。

材料与方法

为此，本研究纳入了 35 例 2 型 DM 患者和 15 名无心脏症状的志愿者（对照组）。对患者和志愿者进行运动耐量试验（ETT）、超声心动图检查以及 Tc-99m MIBI 门控 MPS。对通过 Tc-99m MIBI 门控 MPS 检测出冠状动脉缺血或梗死的患者进行计算机断层扫描冠状动脉造影（CTCA）。对结果进行视觉和统计学分析比较。

结果

本研究显示，35 例 2 型 DM 患者中无症状心肌缺血发生率较高（25.71%，N = 9）。在通过 Tc-99m MIBI 门控 MPS 检测出缺血或梗死的 9 例患者中，有 4 例在 CTCA 中检测出严重 CAD（44.4%）。通过超声心动图、ETT 和生化分析分别在这 4 例患者中检测出左心室舒张功能障碍、缺血模式和 CAD 高风险。在统计评估结束时，我们发现 Tc-99m MIBI 门控 MPS 与 CAD 糖尿病患者的 CTCA、超声心动图、ETT、糖化血红蛋白水平、CAD 风险和糖尿病病程显著相关。

结论

我们提出，Tc-99m MIBI 门控 MPS 是一种可靠的非侵入性方法，可用于检测 2 型 DM 患者的无症状心肌缺血和 CAD。