Ulvi Hizir, Emre Habib, Demir Recep, Aygul Recep, Varoğlu Asuman, Kara Fatih
Atatürk University, Medical Faculty, Department of Neurology, Erzurum, Turkey.
Atatürk University, Medical Faculty, Department of Internal Medicine, Erzurum, Turkey.
Eurasian J Med. 2008 Aug;40(2):79-82.
The recovery period in ischemic cerebrovascular disease is sometimes long and complicated. It is thought that a systemic inflammatory response plays an important role in this process. Therefore, promising studies have reported that neopterin and other cytokines serve as indicators of the inflammatory response. The present study investigated the effects of cerebrovascular diseases on plasma neopterin.
We studied 68 consecutive patients under 65 years of age with cerebrovascular disease; the mean age was 52.08±5.74 years (yrs) (ranging from 39 yrs to 64 yrs; 28 female and 40 male). We also studied 29 randomly selected age-matched healthy subjects (control); the mean age was 49.76±13.11 years (yrs) (ranging from 41 yrs to 62 yrs; 12 female and 17 male). Blood samples for assessing plasma levels of neopterin were usually taken within seven days after admission to the hospital and stored at -20°C until analysis. Serum neopterin levels in all the subjects were measured by Enzyme Immunoassay (EÝA) using the BRAHMS method (Neopterin; Diagnostic GmbH, 16761 Berlin, Germany). Differences between the groups' means were analyzed with the Mann-Whitney U test.
The mean values of neopterin levels in patients (mean neopterin levels in patients, 18.51 ± 11.56 nmol/L; vs. control, 12.26 ± 3.87 nmol/L [p=.001]) were significantly different when compared with the controls.
It has been suggested that the mortality and morbidity associated with cerebrovascular disease could be prevented by a reduction in the inflammatory response. We suggest that plasma neopterin levels were significantly increased. So, the levels of plasma neopterin may be useful monitoring of treatment and course of diseases.
缺血性脑血管疾病的恢复期有时漫长且复杂。认为全身炎症反应在此过程中起重要作用。因此，有前景的研究报道，蝶呤及其他细胞因子可作为炎症反应的指标。本研究调查了脑血管疾病对血浆蝶呤的影响。
我们研究了68例年龄在65岁以下的连续脑血管疾病患者；平均年龄为52.08±5.74岁（范围为39岁至64岁；女性28例，男性40例）。我们还研究了29例随机选取的年龄匹配的健康受试者（对照组）；平均年龄为49.76±13.11岁（范围为41岁至62岁；女性12例，男性17例）。用于评估血浆蝶呤水平的血样通常在入院后7天内采集，并在-20°C保存直至分析。所有受试者的血清蝶呤水平采用BRAHMS方法通过酶免疫测定（EIA）进行测量（蝶呤；Diagnostic GmbH，德国柏林16761）。组间均值差异采用曼-惠特尼U检验进行分析。
与对照组相比，患者蝶呤水平的均值（患者蝶呤平均水平为18.51±11.56 nmol/L；对照组为12.26±3.87 nmol/L [p = 0.001]）有显著差异。
有人提出，通过减轻炎症反应可预防与脑血管疾病相关的死亡率和发病率。我们认为血浆蝶呤水平显著升高。因此，血浆蝶呤水平可能有助于监测疾病的治疗和病程。
