ST段抬高型急性心肌梗死溶栓治疗后梗死面积与QRS电轴变化的相关性
The Correlation between Infarct Size and the QRS Axis Change after Thrombolytic Therapy in ST Elevation Acute Myocardial Infarction.
作者信息
Karakas M Fatih, Bilen Emine, Kurt Mustafa, Arslantas Ugur, Ipek Gokturk, Karakas Esra, Yuksel Isa Oner, Yasar Ayse Saatcı, Bilge Mehmet
机构信息
Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey.
Department of Cardiology, Facult of Medicine, Mustafa Kemal University, Hatay, Turkey.
出版信息
Eurasian J Med. 2012 Apr;44(1):13-7. doi: 10.5152/eajm.2012.03.
OBJECTIVE
Electrocardiography (ECG) may be a practical guiding tool for prognostic infarct sizing in ST elevation acute myocardial infarction (STEAMI). In this study, we sought to find a relation between the infarct size and the change in the QRS axis after thrombolytic therapy.
MATERIALS AND METHODS
Patients with STEAMI who received thrombolytic therapy were selected retrospectively. The mean QRS axes of two ECGs (before and 90 minutes after thrombolytic therapy) were calculated. Creatinine kinase MB (CKMB) was used as the marker of infarct size.
RESULTS
We did not detect any correlation between infarct size and change in the QRS axis with respect to any myocardial infarction MI localizations (p=0.80). However, in the isolated inferior MI group, there was a good correlation between CKMB and change in the QRS axis (r=-0.52 p=0.049).
CONCLUSION
The change in the QRS axis is rarely emphasized, providing a practical and promising tool for evaluating both the efficiency of the thrombolytic therapy and prognostic infarct sizing.
目的
心电图（ECG）可能是评估ST段抬高型急性心肌梗死（STEAMI）预后梗死面积的实用指导工具。在本研究中，我们试图找出梗死面积与溶栓治疗后QRS电轴变化之间的关系。
材料与方法
回顾性选取接受溶栓治疗的STEAMI患者。计算两份心电图（溶栓治疗前和治疗后90分钟）的平均QRS电轴。肌酸激酶同工酶MB（CKMB）用作梗死面积的标志物。
结果
就任何心肌梗死（MI）定位而言，我们未检测到梗死面积与QRS电轴变化之间存在任何相关性（p = 0.80）。然而，在单纯下壁心肌梗死组中，CKMB与QRS电轴变化之间存在良好的相关性（r = -0.52，p = 0.049）。
结论
QRS电轴变化很少受到关注，它为评估溶栓治疗效果和预后梗死面积提供了一种实用且有前景的工具。
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