Montilla P, Navarro J A, Montilla J, Vargas J, Muñoz M C
Departamento de Bioquímica, Facultad de Medicina, Universidad de Córdoba, España.
Rev Esp Fisiol. 1989 Dec;45(4):323-6.
The effect of ACTH (100 micrograms/animal/day, i.p.), dexamethasone (75 micrograms/animal/day, s.c.), both for three consecutive days, and adrenalectomy, with or without dexamethasone, maintained according to the group, one, two or three days, on the plasmatic testosterone and corticosterone levels, has been studied in adult male Wistar rats. ACTH and adrenalectomy produced a high decrease in testosterone levels (p less than 0.001 for the three days studied). Dexamethasone produced lower testosterone levels in the first day followed by partial recuperation between the second and the third days of its administration. Dexamethasone produced the effects mentioned for intact animals. The changes in corticosterone levels were according to an adequate response of the hypothalamus-pituitary-adrenal system under these experimental circumstances. ACTH exerts an inhibitory effect on testosterone secretion in the rat, so that such an effect from the data obtained after adrenalectomy and simultaneous dexamethasone injections, does not seems to be mediated either by the presence of adrenals or high corticosterone levels.
在成年雄性Wistar大鼠中，研究了促肾上腺皮质激素（100微克/动物/天，腹腔注射）、地塞米松（75微克/动物/天，皮下注射）连续三天给药，以及肾上腺切除术（根据组别，有或无地塞米松，持续一、二或三天）对血浆睾酮和皮质酮水平的影响。促肾上腺皮质激素和肾上腺切除术使睾酮水平大幅下降（在所研究的三天中p均小于0.001）。地塞米松在给药第一天使睾酮水平降低，随后在给药的第二天和第三天之间部分恢复。地塞米松对完整动物产生了上述影响。皮质酮水平的变化是下丘脑 - 垂体 - 肾上腺系统在这些实验条件下的适当反应。促肾上腺皮质激素对大鼠睾酮分泌有抑制作用，因此，从肾上腺切除术后和同时注射地塞米松所获得的数据来看，这种作用似乎既不是由肾上腺的存在介导的，也不是由高皮质酮水平介导的。
