School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China ; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Evid Based Complement Alternat Med. 2014;2014:167253. doi: 10.1155/2014/167253. Epub 2014 Dec 18.
Pharmacokinetic characters of rhynchophylline (RIN), gastrodin (GAS), and gastrodigenin (p-hydroxybenzyl alcohol, HBA) were investigated after oral administration of different prescriptions of Yizhi: Yizhi tablets or effective parts of tianma (total saponins from Gastrodiae, EPT) and gouteng (rhynchophylla alkaloids, EPG). At different predetermined time points after administration, the concentrations of GAS, HBA, and RIN in rat plasma were determined by an HPLC-ESI/MS method, and the main pharmacokinetic parameters were investigated. The results showed that the pharmacokinetic parameters C max and AUC0-∞ (P < 0.05) were dramatically different after oral administration of different prescriptions of Yizhi. The data indicated that the pharmacokinetic processes of GAS, HBA, and RIN in rats would interact with each other or be affected by other components in Yizhi. The rationality of the compatibility of Uncaria and Gastrodia elata as a classic "herb pair" has been verified from the pharmacokinetic viewpoint.
钩藤与天麻药对对药组合的合理性从药动学角度得到了验证。本研究考察了不同益智方（益智片剂或天麻总皂苷（EPT）和钩藤生物碱（EPG）有效部位）给药后钩藤碱（RIN）、天麻素（GAS）和对-羟基苯甲醇（HBA）的药代动力学特征。给药后不同预定时间点，采用 HPLC-ESI/MS 法测定大鼠血浆中 GAS、HBA 和 RIN 的浓度，考察主要药代动力学参数。结果表明，不同益智方给药后 C max 和 AUC0-∞的药代动力学参数（P<0.05）有显著差异。结果表明，GAS、HBA 和 RIN 在大鼠体内的药代动力学过程可能相互作用或受益智方中其他成分的影响。
